Investigating the role of sphingolipids in liver disease caused by alcohol.
Sphingolipids in alcoholic liver disease
This study is looking at how alcohol impacts liver health and aims to find new ways to help people with alcoholic liver disease by understanding the role of certain molecules and the gut bacteria involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11105882 on NIH RePORTER |
What this research studies
This research focuses on understanding how alcohol affects liver health, particularly through the lens of sphingolipids, which are important molecules in cellular signaling. The study aims to uncover the mechanisms by which alcohol disrupts liver function and contributes to alcoholic liver disease (ALD). By exploring the interactions between alcohol, liver metabolism, and the gut microbiome, the researchers hope to identify new therapeutic targets. Patients may benefit from insights that could lead to the development of effective treatments for ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcoholic liver disease or those experiencing liver dysfunction related to alcohol consumption.
Not a fit: Patients with liver disease not related to alcohol or those without liver dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients suffering from alcoholic liver disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of sphingolipids in liver disease, indicating that this approach has potential for success.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Zhou, Huiping Rose — Virginia Commonwealth University
- Study coordinator: Zhou, Huiping Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.