Real-World Use of doxy-PEP for STI Prevention in HIV+ individuals, considering alcohol use and gut health
Official title: Real-World Effectiveness of Doxy-PEP for STI Prevention Among People with HIV: Addressing Hazardous Alcohol Use and Microbiome-Driven Inflammation
Funded at University of Florida · NIH-11470392 · Data updated 2026-11-12
A real-world study will track how well doxycycline post-exposure prophylaxis works to prevent STIs in men with HIV who have sex with men, especially when alcohol use and gut inflammation are involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 20, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $706,684 |
| NIH project number | 1R01AA033577-01 |
| Project ID | NIH-11470392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are men with HIV who have sex with men, are at risk for bacterial STIs, and are considering or currently using doxy-PEP.
✕Less likely to help
People who do not use doxy-PEP or who are not at risk for STIs may not benefit from this research.
What this research studies
This project will follow 275 men with HIV who have sex with men to see how doxy-PEP performs outside of clinical trials. Researchers will collect data over time using digital tools to monitor dosing, adherence, alcohol use, and STI outcomes, while also looking at gut microbiome and inflammatory markers. The study aims to understand how real-life factors like heavy drinking may affect doxy-PEP effectiveness and gut health. Results could guide safer, more effective use of doxy-PEP in routine care for people living with HIV. The approach combines long-term observation with biologic and behavioral measurements to capture real-world impact.
Why it matters
Potential benefit: If successful, the study could inform guidelines for doxy-PEP use in people with HIV, helping reduce STI risk while accounting for alcohol use and gut health.
How similar studies have gone: Previous trials showed doxy-PEP can prevent STIs in controlled settings; this study tests real-world effectiveness and factors that could enhance or hinder benefit.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Westmoreland, Drew Anne — University of Florida
- Study coordinator: Westmoreland, Drew Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.