Economic and relationship support to help couples in Malawi reduce heavy drinking

A randomized controlled trial of an economic and relationship-strengthening intervention to reduce alcohol use in Malawi

NIH-funded research University of California, San Francisco · NIH-11504799

This program offers HIV-affected couples in Malawi combined financial coaching and relationship skills to help men drink less and support HIV treatment adherence.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Francisco NIH-funded
Lab location1 site (San Francisco, United States)
Project IDNIH-11504799 on NIH RePORTER

What this research studies

Couples living with HIV in Malawi are randomly assigned to receive Mlambe — a program that teaches financial planning, provides incentives to redirect money away from alcohol, and offers communication and relationship-strengthening sessions — or to continue usual care. Local facilitators work with both partners on money-management goals, reduce alcohol-related spending, and practice better communication to reduce conflict. The study measures changes in alcohol use, couple relationships, and adherence to antiretroviral therapy over time. Participants provide information at regular visits so researchers can compare outcomes between the two groups.

Who could benefit from this research

Good fit: Ideal candidates are couples in Malawi affected by HIV in which one or both partners, especially men, engage in heavy alcohol use and are on or eligible for ART.

Not a fit: Single people, those without alcohol-related problems, individuals living outside Malawi, or persons with severe alcohol dependence needing medical detox are unlikely to benefit from this intervention.

Why it matters

Potential benefit: If successful, the program could lower heavy drinking, reduce financial strain and conflict within couples, and improve adherence to HIV treatment.

How similar studies have performed: A prior pilot trial of Mlambe found the approach was feasible and acceptable for couples and showed promising effects on drinking, relationships, and health outcomes, but a larger randomized trial is needed for confirmation.

Where this research is happening

San Francisco, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.