Sponsor or institution
Clinical trials and research at Wayne State University
As of November 12, 2026, Find a Trial lists 25 clinical trials run by Wayne State University that are recruiting, at sites in 2 countries (most in United States (23), South Africa (2)). By phase: Phase 2 (3), Phase 1/2 (2), Early Phase 1 (2), Phase 1 (1). There are also 347 NIH-funded research projects at this institution, with $160.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 25Clinical trials
- 347NIH research projects
- 2Countries
Newest trials
All recruiting trials (25)
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See if the Parenting Young Children Check-up helps with behavior in kids ages 2-5
This trial tests the Parenting Young Children Check-up to see if it improves behavior and reduces parenting stress for families with young children in a Detroit pediatric clinic serving low-income families.
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Parenting Young Children Check-up in a Detroit clinic
This trial tests whether the Parenting Young Children Check-up helps improve behavior, parenting, and stress for parents of 2- to 5-year-olds compared with usual care.
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Prenatal choline supplementation to support fetal brain development
This study tests whether giving pregnant people choline can help their babies' brain development and growth, compared with a placebo, when alcohol exposure is not present.
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Using virtual reality to trigger exercise-like responses in sedentary adults
This study will test whether repeated short VR sessions that mimic exercise can produce exercise-like protein changes and improved endurance in sedentary adults with prediabetes.
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Timing of opioid administration and breathing changes after surgery
This study watches adults who had general anesthesia and receive opioids after surgery to see if opioid timing and dose affect breathing changes measured by minute ventilation.
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Behavioral Activation delivered by peer recovery specialists in a community clinic
This project will test whether Behavioral Activation delivered by peer recovery specialists helps adults with depression (and co-occurring substance use disorders) who receive care at a community behavioral health center.
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Neurofeedback for Well-Being in people waiting for OCD therapy
This study tests whether a neurofeedback program can improve overall well-being for adults on a waitlist for OCD treatment and whether any improvement relates to changes in OCD, PTSD, and trauma-related symptoms.
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Intravenous arginine to help treat diabetic ketoacidosis in people with type 2 diabetes
This study tests whether a single IV dose of arginine given early in DKA can safely boost your own insulin and help adults with ketone-prone type 2 diabetes recover faster.
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Cannabidiol-assisted learning to help manage generalized anxiety
This trial will test whether adding FDA-approved cannabidiol (Epidiolex) to brief cognitive behavioral therapy helps adults 18–45 with generalized anxiety disorder improve emotion regulation and reduce anxiety symptoms.
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Single-session CBT, PRT, or EAET for chronic musculoskeletal pain
This trial tests whether a single 90-minute session of CBT, Pain Reprocessing Therapy (PRT), or Emotion Awareness and Expression Therapy (EAET) reduces pain and improves mood for adults in the U.S. with chronic musculoskeletal pain compared with no treatment.
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Enhanced operating room curriculum to improve medical student gynecologic surgery skills
This trial will test whether adding an enhanced surgical OR course helps Wayne State medical students learn gynecologic procedures and feel more comfortable managing gynecologic emergencies.
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Augmented reality-enhanced exposure therapy for PTSD in U.S. military personnel
This tests whether adding augmented reality to standard exposure therapy helps U.S. military veterans and active-duty adults with PTSD.
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Improving cardiometabolic and blood pressure health in Detroit through early prevention
This project will follow adults seen at Wayne Health mobile units who have elevated blood pressure to see if tracking their care, sending text reminders, and offering home monitoring helps improve blood pressure control.
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Warrior CARE: Cannabis Behavioral Health
This study tests whether different cannabis compounds (THC, CBD, or THC+CBD) or placebo can help veterans with PTSD and suicidal thoughts over 12 weeks.
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Using Ondansetron to Prevent Itching in Cesarean Section Patients
This study tests if giving ondansetron can help prevent itching and nausea in women who have a cesarean section with spinal anesthesia.
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Using exercise to help adolescents manage fear and anxiety
This study is testing if moderate exercise can help teenagers aged 14-17 manage their fear and anxiety better by improving how their brains work.
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Family intervention for Black teens with type 1 diabetes
This study is testing a new mobile health program to see if it can help Black teens with type 1 diabetes manage their blood sugar better and improve their family relationships.
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Improving memory and decision-making in at-risk youth
This study is testing a computer-based memory training program to see if it can help young people aged 11 to 15 in underserved areas make better decisions and reduce their risk of substance misuse.
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Mapping brain function in epilepsy patients
This study is testing a new brain mapping technique to see if it can help doctors better plan epilepsy surgery and improve language outcomes for patients.
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Comparing Factor VIII and Emicizumab for Preventing Bleeding in Hemophilia A Patients Playing Sports
This study tests whether Factor VIII or Emicizumab is better at preventing bleeding in boys aged 6 to 19 with Hemophilia A while they play sports.
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Investigating the effects of opioids and benzodiazepines on substance abuse
This study is trying to see how using opioids and benzodiazepines together affects emotions and decision-making in people who have struggled with substance abuse.
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Examining the effects of ocrelizumab in African American and Caucasian patients with relapsing multiple sclerosis
This study is testing how well ocrelizumab works for treating relapsing multiple sclerosis in African American and Caucasian patients to see if there are any differences in how the disease progresses.
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Prenatal choline supplementation to reduce effects of alcohol on fetal development
This study is testing if giving pregnant women who drink heavily a supplement called choline can help protect their babies from the harmful effects of alcohol during pregnancy.
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Using battlefield acupuncture to relieve pain in hidradenitis suppurativa
This study is testing if battlefield acupuncture can help reduce pain for people with hidradenitis suppurativa.
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Understanding opioid and benzodiazepine abuse patterns
This study is trying to understand how people being treated for Substance Use Disorder in Wayne County use both opioids and benzodiazepines together, to see if this can help improve their treatment.
NIH-funded research (newest 40 of 347)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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New MRI tools to better plan pediatric epilepsy surgery
A new MRI-based approach helps doctors decide the best time to surgically remove brain tissue in children with difficult-to-control seizures.
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EBV reactivation and how it changes human cells in HIV-related cancers
This NIH grant looks at how Epstein-Barr virus reactivation affects human cells and may contribute to cancers in people with HIV/AIDS.
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Programmed splicing derangement and EBV host cell shut-off in HIV/ AIDS-related cancers
Researchers are studying how Epstein-Barr virus reprograms human cells in people with HIV/AIDS to promote cancer development and autoimmune diseases.
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PFAS may speed up artery disease by changing bile acids
Aims to see if PFAS chemicals make cholesterol rise and arteries more likely to harden, using a human-similar mouse model to understand how this could affect people.
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Synthesis and measurement of cyanotoxins to understand human exposure from water and air
This project will make precise chemical standards and measurement methods for cyanotoxins from harmful algal blooms to better estimate how people might be exposed through drinking water and air.
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Personalized cancer subtyping and risk prediction with multi-omics data
A cancer research project aims to classify tumors and predict risk by integrating multiple molecular data types to tailor treatments for patients.
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AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
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A harmonized plan to map brain regions to better understand dementia
Aimed at standardizing how brain regions in the medial temporal lobe are labeled in high-resolution MRI to improve dementia research and patient care.
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A harmonized protocol to map memory-related brain regions for dementia research
This grant aims to standardize how doctors measure small memory-related brain areas on MRI to improve dementia research.
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A standardized way to map memory-related brain regions to help diagnose and study dementia
Researchers are creating a harmonized method to precisely map parts of the memory brain region on high-resolution MRI to improve studies of Alzheimer's disease and related dementias.
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Chemical tools to map protein modifications in cancer biology
This grant aims to create new chemical methods to study how protein post-translational modifications influence cancer biology and drug targets.
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Materials and macromolecules tailored for micro and nanoscale chemistry
A NIH grant proposes making more chemical reactions work better with tiny, automated machines to speed up making complex molecules and drugs.
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Systemic imaging probes for detecting tissue oxygen levels in cancer and other diseases
A researcher aims to develop a new europium-based MRI contrast agent that can be given systemically to visualize oxygen levels (hypoxia) in cancer and other diseases.
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Stopping an enzyme called Transglutaminase 2 to prevent cancer-related muscle loss
This work explores whether blocking an enzyme called Transglutaminase 2 can stop or reverse the severe muscle wasting that often affects people with pancreatic cancer.
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Canagliflozin to protect the aging brain and improve cognition in Alzheimer’s disease
Aging is linked to Alzheimer’s and this project tests whether the diabetes drug canagliflozin can help brain function and reduce inflammation in older adults with or at risk for Alzheimer’s/dementia.
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Host immune activation after targeted antibody therapy in autoimmune disease models
This grant studies how a patient’s own immune system responds to targeted antibody therapy, aiming to reveal factors that boost beneficial anti-tumor-like immunity.
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Understanding how fat cells control fat storage and breakdown
A research project at Wayne State University explores how a protein called ABHD5 helps fat cells manage storage and release of fats, which could impact metabolic health.
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Placental responses to maternal viral infection shape sex-specific offspring immunity
A mother’s viral infection during pregnancy can change how her baby’s immune system develops, potentially making some babies more prone to infections after birth.
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Tryptophan-based PET imaging to map glioma metabolism
A new PET imaging tracer uses labeled tryptophan to visualize brain tumor metabolism in adults with gliomas, helping doctors see tumors more clearly and tailor treatment.
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Molecular signals of aging with BTEX exposure across aging
This grant asks how common air pollutants like benzene and friends speed aging in adults and affect brain and body health.
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Antibody approaches to prevent weight and muscle loss in pancreatic cancer
Trying antibody-based therapies to stop or reduce muscle wasting and weight loss in people with pancreatic cancer.
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COMISA care pathway in cancer treatment
A team at Wayne State University is testing a simple, clinic-based plan to screen cancer patients for sleep problems and connect them quickly with care for insomnia and sleep apnea.
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How muscle signals affect insulin resistance in adults with diabetes
This grant explores how patterns of muscle protein signals relate to insulin resistance in adults, with the goal of better understanding why some lean people and some with obesity develop or avoid type 2 diabetes.
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Retinal Cell Loss in Diabetic Retinopathy
This project looks at how mitochondrial problems and a specific kind of cell death called ferroptosis may cause retinal cells to die in people with diabetes-related eye disease.
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MAFA and MAFB help mature pancreatic beta cells stay healthy
This grant studies how two proteins, MAFA and MAFB, help human insulin-producing beta cells mature properly, with the aim of understanding why beta cells lose identity in type 2 diabetes.
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Vitreous metabolism changes during eye infections from bacteria and fungi
This project looks at tiny chemical changes in the eye fluid to understand and diagnose endophthalmitis caused by bacteria or fungi.
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Enhancing treatments for myeloid leukemia with Down syndrome
This grant explores how bone marrow support cells affect treatment response in children with Down syndrome–related leukemia and aims to improve chemotherapy effectiveness.
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Impact of vaping components on pregnancy and newborn lungs
This grant looks at how e-cigarette vapors, especially nicotine, affect pregnant people and their babies, focusing on how exposure might change baby lung development and infection risk.
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New computer-driven models to study membrane proteins and lipid metabolism
A researcher at Wayne State University is developing advanced computer models to understand how membrane proteins and lipid metabolism work, with a focus on proteins involved in viruses like SARS-CoV-2 and diseases such as cancer and diabetes.
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Chemical Analysis Core supports safer environments by measuring toxic VOCs
A specialized core lab helps researchers and communities in post-industrial cities measure and track volatile organic compounds to protect mothers and babies from exposure.
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Community engagement core to reduce VOC exposure in Detroit
A community-focused program in Detroit helps people learn about and reduce risks from volatile organic compounds in air and water.
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Data Management & Analysis Core for Environmental Health Research
A data-and-analysis service core helps researchers study how environmental pollutants affect mothers and babies, using advanced statistics and data management to make findings reliable and shareable.
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Administrative Core of CLEAR Centers for environmental health in Detroit
This grant supports a central leadership and coordination hub to address how environmental factors like volatile organic chemicals may contribute to high preterm birth in Detroit.
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Volatile Organic Compounds and Preterm Birth in Detroit
A large study will follow about 1,100 pregnant women in Detroit to see if exposure to common air pollutants is linked to starting birth earlier than expected in this city.
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Impact of VOCs in Pregnancy on Baby and Mom’s Health
This project looks at how exposure to airborne chemicals during pregnancy could affect a mom’s health and a baby’s growth and immune system.
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Integrated IoT Sensing and Edge Computing with Bayesian Network for Vapor Intrusion Exposure
A patient-facing version would explain how this project uses smart sensors and a smart model to understand and reduce exposure to hazardous vapors in urban homes and workplaces.
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Aboveground clues to find hidden VOC vapors in cities
A project at Wayne State University will use plants to help find hidden VOC contamination in urban soils and link it to indoor air quality in basements.
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Center for Leadership in Environmental Awareness and Research
A center in Detroit is testing how exposure to common air and soil pollutants from landfills and polluted sites may affect pregnancy and baby health.
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A peer-delivered program to improve depression and substance use in low-resource communities
A community-based, peer-delivered approach is being tested to help adults in economically challenged areas with depression and substance use.
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Octopamine and exercise adaptation in fruit flies and humans
This grant explores how octopamine signals in the brain and muscles help the body enjoy exercise benefits, starting in fruit flies and moving toward a VR-based approach for sedentary people.
Quick answers
How many clinical trials run by Wayne State University are recruiting right now?
25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (23 trials), South Africa (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 3, Phase 1/2: 2, Early Phase 1: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.