Programmed splicing derangement and EBV host cell shut-off in HIV/ AIDS-related cancers
Official title: Programmed splicing derangement as new EBV host cell shut-off mechanism
Funded at Wayne State University · NIH-11577638 · Data updated 2026-11-12
Researchers are studying how Epstein-Barr virus reprograms human cells in people with HIV/AIDS to promote cancer development and autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | July 1, 2026 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $318,835 |
| NIH project number | 7R01CA262090-06 |
| Project ID | NIH-11577638 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with HIV/AIDS who are at risk for EBV-associated diseases or who have EBV-related conditions.
✕Less likely to help
Patients without EBV-related manifestations or HIV infection may not directly benefit.
What this research studies
This project focuses on how EBV changes host cell RNA processing to support viral replication and cancer progression in people with HIV/AIDS. By examining the virus-host interactions, scientists aim to identify new points where the virus disrupts normal cell function. The study uses patient-relevant biology and laboratory models to explore how alternative RNA splicing and host shut-off mechanisms contribute to EBV-associated diseases. Findings could point to new strategies to prevent or treat EBV-related cancers in the HIV-infected population.
Why it matters
Potential benefit: If successful, the work could lead to new approaches to prevent or treat EBV-related cancers in people living with HIV/AIDS.
How similar studies have gone: Previous research has shown links between EBV lytic replication and cancer, suggesting this line of inquiry may yield meaningful insights but remains exploratory.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Flemington, Erik K — Wayne State University
- Study coordinator: Flemington, Erik K
Related research
Other NIH-funded projects on the same topics.
-
New MRI tools to better plan pediatric epilepsy surgery
A new MRI-based approach helps doctors decide the best time to surgically remove brain tissue in children with difficult-to-control seizures.
-
EBV reactivation and how it changes human cells in HIV-related cancers
This NIH grant looks at how Epstein-Barr virus reactivation affects human cells and may contribute to cancers in people with HIV/AIDS.
-
PFAS may speed up artery disease by changing bile acids
Aims to see if PFAS chemicals make cholesterol rise and arteries more likely to harden, using a human-similar mouse model to understand how this could affect people.
-
Synthesis and measurement of cyanotoxins to understand human exposure from water and air
This project will make precise chemical standards and measurement methods for cyanotoxins from harmful algal blooms to better estimate how people might be exposed through drinking water and air.
-
Personalized cancer subtyping and risk prediction with multi-omics data
A cancer research project aims to classify tumors and predict risk by integrating multiple molecular data types to tailor treatments for patients.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.