Chemical tools to map protein modifications in cancer biology
Official title: Chemical Approaches to Study Protein Post-translational Modifications
Funded at Wayne State University · NIH-11529332 · Data updated 2026-11-12
This grant aims to create new chemical methods to study how protein post-translational modifications influence cancer biology and drug targets.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | June 1, 2019 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $65,430 |
| NIH project number | 3R35GM131821-08S1 |
| Project ID | NIH-11529332 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with cancers or disorders where protein modification pathways are dysregulated may be eligible for future translational efforts emerging from this research.
✕Less likely to help
Trial participants are not explicitly described in this grant; direct patient participation is not a current component of the described aims.
What this research studies
Researchers will develop innovative chemical tools to link specific protein modifications to cellular behavior in cancer. The work focuses on phosphorylation and acetylation, and how enzymes that regulate these marks affect disease processes. The project builds on prior methods to label modified proteins and plans to expand these approaches over the next several years. The ultimate goal is to improve understanding of disease mechanisms and support the design of targeted therapies.
Why it matters
Potential benefit: If successful, patients could benefit from clearer insights into how cancer-related protein modifications drive disease and from new avenues for therapeutic development.
How similar studies have gone: Previous methods for studying protein modifications have shown promise, and this project extends those chemical approaches to uncover additional roles in cell biology.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Pflum, Mary Kay H — Wayne State University
- Study coordinator: Pflum, Mary Kay H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.