Timing of opioid administration and breathing changes after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates whether when and how much opioids are given after general anesthesia influences postoperative breathing, using minute ventilation as the main measure. It focuses on spontaneously breathing, non-intubated patients in the post-anesthesia care unit and looks for a drop of 20% or more in predicted minute ventilation. A secondary goal is to understand dose-related effects on minute ventilation. The study has been initiated by Wayne State University at Detroit Medical Center and aims to clarify the relationship between perioperative opioid use and postoperative respiratory depression in at-risk populations. Monitoring is performed with respiratory volume techniques to identify potential opportunities for safer analgesia strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent
* Adults ≥18 years of age and ≤85 years of age
* Patients planned for general anesthesia with an expected anesthetic time of at least 2 hours
* Patients expected to receive postoperative opioid analgesia

Exclusion Criteria:

* Non-operative procedure (imaging)
* Patients not admitted to the PACU postoperatively
* Use of patient-controlled analgesia systems
* Female patients who are pregnant or breastfeeding
* Patients with asymmetric lung disease
* American Society of Anesthesiologists (ASA) classification V
* Emergency surgery (ASA E Modifier)

Where it's running

• Detroit Medical Center
  Detroit, Michigan, United States Recruiting

Study contacts

• Principal investigator: Wael Saasouh, MD — Wayne State University
• Study coordinator: George M McKelvey, PhD
• Email: George.McKelvey@northstaranesthesia.com
• Phone: 3135986036

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.