Understanding opioid and benzodiazepine abuse patterns
Official title: Opioid/Benzodiazepine Polydrug Abuse: Integrating Research on Mechanisms, Treatment and Policies
Run by Wayne State University · NCT03696017 · Data updated 2026-11-12
This study is trying to understand how people being treated for Substance Use Disorder in Wayne County use both opioids and benzodiazepines together, to see if this can help improve their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Wayne State University Academic / other |
| Locations | 1 site (Detroit, Michigan) |
| Status | Recruiting |
| Started | February 8, 2019 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | December 30, 2025 |
| Trial ID | NCT03696017 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals recently admitted to treatment for Substance Use Disorder who are using opioids, benzodiazepines, or both.
✕Probably not a fit
Patients with severe psychiatric disorders, such as current psychosis or bipolar disorder, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the patterns of polysubstance abuse involving opioids and benzodiazepines among patients currently undergoing treatment for Substance Use Disorder in Wayne County. Up to 120 participants will undergo a comprehensive 6-hour assessment that includes clinical evaluations and hypothesis-driven measures related to mental health and substance use. The study will utilize various assessment tools, including interviews and questionnaires, to gather data on affective dysregulation, neurocognition, and substance use behaviors. The findings may help identify phenotypes that could be targeted to reduce the risks associated with polysubstance abuse.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients struggling with polysubstance abuse, potentially reducing overdose risks and improving outcomes.
How similar studies have gone: While there is limited data on this specific approach, previous studies have highlighted the dangers of polysubstance abuse, indicating a need for further investigation in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Recently admitted and/or not clinically stable in treatment for Substance Use Disorder (SUD) in Wayne County * Using opioids, benzodiazepines (BZD), or BZD/opioid. Exclusion Criteria: * Participants with current psychosis, bipolar disorder, or severe depression (i.e. severe psychiatric disorder) * Individuals with serious neurological disorders, e.g. brain tumor, history of stroke, history of traumatic brain injury w/ loss of consciousness * Cognitive impairment (IQ\<80)
Where it's running
-
Tolan Park Medical Building
Detroit, Michigan, United States Recruiting
Study contacts
- Principal investigator: Mark Greenwald, PhD — Wayne State University
- Study coordinator: Heidi Aguas
- Email: gh7962@wayne.edu
- Phone: 3139933960
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Canadian Emergency Department Opioid Registry (CEDRN)
This project will create a national emergency department registry to collect information on people of all ages who come to EDs with suspected or confirmed opioid poisoning to see if those data can guide better care and prevent deaths.
-
Using motivational interviewing and mindfulness to help reduce substance use
This study is testing whether combining motivational interviewing and mindfulness techniques can help people who struggle with using multiple substances, like opioids and tobacco, to reduce their use.
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Investigating the effects of opioids and benzodiazepines on substance abuse
This study is trying to see how using opioids and benzodiazepines together affects emotions and decision-making in people who have struggled with substance abuse.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.