Clinical trial Recruiting at 1 site Observational Ages 18 to 70

Understanding opioid and benzodiazepine abuse patterns

Official title: Opioid/Benzodiazepine Polydrug Abuse: Integrating Research on Mechanisms, Treatment and Policies

Run by Wayne State University · NCT03696017 · Data updated 2026-11-12

This study is trying to understand how people being treated for Substance Use Disorder in Wayne County use both opioids and benzodiazepines together, to see if this can help improve their treatment.

Quick facts

Study typeObservational
Ages18 Years to 70 Years
SexAll
Enrollment120 (estimated)
SponsorWayne State University
Academic / other
Locations1 site (Detroit, Michigan)
StatusRecruiting
StartedFebruary 8, 2019
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedDecember 30, 2025
Trial IDNCT03696017 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals recently admitted to treatment for Substance Use Disorder who are using opioids, benzodiazepines, or both.

Probably not a fit

Patients with severe psychiatric disorders, such as current psychosis or bipolar disorder, will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the patterns of polysubstance abuse involving opioids and benzodiazepines among patients currently undergoing treatment for Substance Use Disorder in Wayne County. Up to 120 participants will undergo a comprehensive 6-hour assessment that includes clinical evaluations and hypothesis-driven measures related to mental health and substance use. The study will utilize various assessment tools, including interviews and questionnaires, to gather data on affective dysregulation, neurocognition, and substance use behaviors. The findings may help identify phenotypes that could be targeted to reduce the risks associated with polysubstance abuse.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies for patients struggling with polysubstance abuse, potentially reducing overdose risks and improving outcomes.

How similar studies have gone: While there is limited data on this specific approach, previous studies have highlighted the dangers of polysubstance abuse, indicating a need for further investigation in this area.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Recently admitted and/or not clinically stable in treatment for Substance Use Disorder (SUD) in Wayne County
* Using opioids, benzodiazepines (BZD), or BZD/opioid.

Exclusion Criteria:

* Participants with current psychosis, bipolar disorder, or severe depression (i.e. severe psychiatric disorder)
* Individuals with serious neurological disorders, e.g. brain tumor, history of stroke, history of traumatic brain injury w/ loss of consciousness
* Cognitive impairment (IQ\<80)

Where it's running

  • Tolan Park Medical Building
    Detroit, Michigan, United States
    Recruiting

Study contacts

  • Principal investigator: Mark Greenwald, PhD — Wayne State University
  • Study coordinator: Heidi Aguas
  • Email: gh7962@wayne.edu
  • Phone: 3139933960

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Canadian Emergency Department Opioid Registry (CEDRN)

    This project will create a national emergency department registry to collect information on people of all ages who come to EDs with suspected or confirmed opioid poisoning to see if those data can guide better care and prevent deaths.

    Recruiting University of British Columbia · Vancouver, British Columbia · NCT07466784

  • Using motivational interviewing and mindfulness to help reduce substance use

    This study is testing whether combining motivational interviewing and mindfulness techniques can help people who struggle with using multiple substances, like opioids and tobacco, to reduce their use.

    Recruiting at 2 sites Phase 3 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT06033599

  • Investigating the effects of opioids and benzodiazepines on substance abuse

    This study is trying to see how using opioids and benzodiazepines together affects emotions and decision-making in people who have struggled with substance abuse.

    Recruiting Phase 2 Wayne State University · Detroit, Michigan · NCT05006079

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.