A harmonized protocol to map memory-related brain regions for dementia research
Official title: A harmonized medial temporal lobe subregion segmentation protocol: an essential element for dementia research
Funded at Wayne State University · NIH-11541308 · Data updated 2026-11-12
This grant aims to standardize how doctors measure small memory-related brain areas on MRI to improve dementia research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | March 1, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $166,789 |
| NIH project number | 3R01AG070592-05S1 |
| Project ID | NIH-11541308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable as a patient in this study; imaging data is derived from scans, not a direct patient intervention.
✕Less likely to help
No direct patient involvement in this protocol-focused project; it analyzes imaging methods.
What this research studies
Researchers at Wayne State University want to create one shared, reliable method to identify and label subregions within the medial temporal lobe on high-resolution brain scans. By standardizing segmentation, they hope to reduce conflicting results across studies of Alzheimer’s disease and related conditions. The project builds on prior work by the Hippocampal Subfields Group and uses advanced MRI data to establish validity and consistency in how these brain regions are outlined. The outcome should make future imaging studies more comparable and help researchers better understand how memory-related brain changes occur in dementia.
Why it matters
Potential benefit: A clearer, standardized imaging protocol could improve the accuracy of dementia research and potentially speed the development of diagnostic tools.
How similar studies have gone: Previous work showed promising progress in harmonizing hippocampal subfield segmentation, but standardization remains a gap that this project aims to fill.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Daugherty, Ana Marie — Wayne State University
- Study coordinator: Daugherty, Ana Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.