Sponsor or institution

Clinical trials and research at University of Cincinnati

• 35Clinical trials
• 366NIH research projects
• 6Countries

Newest trials

All recruiting trials (35)

• Using nerve monitoring to help protect nerves during breast cancer lymph node surgery

  This study tests whether intraoperative nerve monitoring and bipolar electrocautery during axillary lymph node dissection can help identify and preserve nerves to reduce post-surgical neuropathic pain.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT07528638

• Lowering nodal and primary tumor radiation dose in HPV-positive oropharyngeal cancer

  This phase II study tests whether reducing radiation doses to regions without visible cancer, while keeping the main tumor dose the same, can treat HPV-positive OPSCC with fewer side effects.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT07497607

• Measuring the mechanical cost of walking in people with stroke-related walking problems

  It tests a new biomechanical way to measure how much energy walking uses in people with walking problems after stroke.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT07494890

• Combining N-acetylcysteine and mindfulness-based cognitive therapy to target prefrontal glutamate in mildly depressed youth

  This trial will test whether taking N-acetylcysteine (NAC) together with mindfulness-based cognitive therapy (MBCT) helps mildly depressed teens and young adults by changing prefrontal glutamate levels and brain connectivity.

  Recruiting Phase 3 University of Cincinnati · Cincinnati, Ohio · NCT07464886

• Early pelvic floor physical therapy after pelvic radiation for cervical cancer

  This will try pelvic floor physical therapy starting four weeks after pelvic radiation to see if it lowers fecal incontinence in women treated for cervical cancer.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT07447895

• Oral 5‑strain probiotic to reduce bowel side effects during pelvic radiation

  This pilot will try giving an oral 5‑strain probiotic (Pendulum Glucose Control) to adults receiving pelvic radiation to see if it safely reduces gastrointestinal side effects.

  Recruiting Early Phase 1 University of Cincinnati · Cincinnati, Ohio · NCT07231588

• Recombinant factor VIIa treatment for acute intracerebral hemorrhage

  This trial will try recombinant factor VIIa in adults with spontaneous intracerebral hemorrhage to see if very early treatment reduces bleeding and improves 90‑day outcomes.

  Recruiting at 88 sites Phase 3 University of Cincinnati · Birmingham, Alabama and 87 other locations · NCT07227246

• Boosting immunotherapy with low-dose liver radiation

  This trial tests whether adding low-dose radiation to the liver before immunotherapy helps people with melanoma or non-small cell lung cancer who have liver metastases live longer without their disease worsening.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT07225036

• Pembrolizumab plus short-course proton or X‑ray radiation before salvage surgery for recurrent head and neck cancer

  This study will try short-course proton or X‑ray radiation followed by pembrolizumab before salvage surgery in adults with recurrent head and neck squamous cell carcinoma who previously received radiation.

  Recruiting Phase 1/2 University of Cincinnati · Cincinnati, Ohio · NCT07213934

• Epcoritamab given after 2nd-generation BTK inhibitors for CLL/SLL

  This trial will try giving subcutaneous epcoritamab for up to 12 cycles to adults with CLL/SLL who have been on a second‑generation BTK inhibitor for at least 12 months to see if it can deepen responses to a complete remission with undetectable MRD so therapy can be stopped.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT07108998

• Imaging to detect impaired microcirculatory reperfusion after clot removal

  This project tests whether CT perfusion scans done after clot removal can spot poor tiny-vessel blood flow in adults with large-vessel ischemic stroke.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT07099599

• Intermittent versus continuous venetoclax with acalabrutinib in CLL/SLL

  This will test whether giving venetoclax intermittently or continuously together with acalabrutinib helps people with previously untreated CLL or SLL.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT07014917

• LP-168 plus obinutuzumab for previously treated and BTK T474I‑mutated CLL/SLL

  This trial tests whether adding LP-168 to obinutuzumab helps people with previously treated CLL/SLL, including those with the BTK T474I gatekeeper mutation, achieve deeper remissions.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT06978088

• Improving DHA delivery in older adults at risk for dementia

  This study is testing whether two different types of DHA supplements can improve brain health in older adults who are showing early signs of memory problems.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06933095

• Using brain stimulation to improve cognitive recovery in traumatic brain injury

  This study is testing if a type of brain stimulation can help improve thinking skills in people with moderate to severe traumatic brain injury.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06871124

• Exploring spinal stimulation for treating major depressive disorder

  This study is testing if a new type of spinal stimulation can help people with major depressive disorder feel better by targeting specific pathways in the spine and brain.

  Recruiting Phase 1/2 University of Cincinnati · Mason, Ohio · NCT06795451

• Tracking sensory changes after a stroke to improve walking and balance

  This study is trying to see how changes in feeling and movement after a stroke affect walking and balance in stroke survivors to help improve their recovery.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06727097

• Acupuncture for pain in sickle cell disease

  This trial will test whether traditional needle acupuncture or non‑needle laser acupuncture can reduce pain and change brain and sensory responses in adolescents and adults with sickle cell disease.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06725550

• Tirzepatide with buprenorphine for opioid use disorder

  This trial will test whether adding weekly tirzepatide injections to buprenorphine helps adults with moderate to severe opioid use disorder stay in treatment, reduce opioid use, and improve sleep.

  Recruiting at 9 sites Phase 2 University of Cincinnati · Jacksonville, Florida and 8 other locations · NCT06651177

• Comparing two nerve-block options to reduce pain after total mastectomy.

  This test tries whether a PECS-II block given before surgery or a pectoral block given during surgery, using bupivacaine or liposomal bupivacaine, provides better pain control after total mastectomy for breast cancer or high-risk patients.

  Recruiting Phase 4 University of Cincinnati · Cincinnati, Ohio · NCT06574022

• C-peptide's effect on blood sugar regulation during hypoglycemia

  This study tests if adding C-peptide to insulin can help people with type 1 diabetes and healthy individuals better manage their blood sugar during low blood sugar episodes.

  Recruiting Early Phase 1 University of Cincinnati · Cincinnati, Ohio · NCT06470295

• Lattice radiation therapy for treating large tumors

  This study is testing a new type of radiation therapy called lattice radiation therapy to see if it works better than standard treatment for people with large tumors.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT06416007

• Comparing two surgical methods for fixing acetabular fractures

  This study is testing two different surgical methods for fixing hip fractures to see which one helps patients heal better and reduces complications.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06409559

• Exercise program for stroke recovery

  This study is testing whether moderate or vigorous walking exercise with a physical therapist helps people who had a stroke improve their walking ability.

  Recruiting at 3 sites University of Cincinnati · Newark, Delaware and 2 other locations · NCT06268041

• Examining hormonal responses to meals in cystic fibrosis patients

  This study looks at how people with cystic fibrosis react hormonally to meals to see if these responses are linked to problems with blood sugar control.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06163482

• Effects of Lingual Endurance Exercise on Swallowing After Stroke

  This study is testing a new tongue exercise to see if it can help people who have trouble swallowing after a stroke.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06072924

• Comparing endovascular treatment and medical management for stroke patients with disabilities

  This study is testing whether a procedure called endovascular thrombectomy can help stroke patients with existing disabilities feel better compared to just using medication.

  Recruiting at 33 sites University of Cincinnati · Birmingham, Alabama and 34 other locations · NCT05911568

• Using real-time brain monitoring to improve treatment for severe traumatic brain injury

  This study is testing if real-time brain monitoring can help doctors provide better care for patients recovering from severe traumatic brain injuries by identifying specific brain issues that need targeted treatment.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT05337618

• Wellness program for caregivers of patients with traumatic brain injuries

  This study tests a wellness program designed to help caregivers of patients with serious brain injuries feel better and manage their challenges more effectively compared to regular support services.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT05307640

• Understanding brain changes in children with developmental language disorder

  This study is trying to see how treatment affects grammar learning in preschoolers with developmental language disorder by looking at their brain changes before and after therapy.

  Recruiting at 4 sites University of Cincinnati · Cincinati, Ohio and 5 other locations · NCT05268341

• Pharmacogenetically-guided treatment for anxiety in kids

  This study is testing if adjusting anxiety medication based on kids' genetics helps them feel better compared to standard dosing.

  Recruiting Phase 4 University of Cincinnati · Cincinnati, Ohio · NCT04623099

• Using Continuous Passive Motion for Patients with Pelvic and Knee Fractures

  This study is testing if a special movement therapy after surgery for pelvic and knee fractures can help patients feel less pain and recover better compared to regular care.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT04389749

• Comparing treatments for Zenker Diverticulum and related swallowing issues

  This study is testing which treatment method works better for people with Zenker's diverticulum and swallowing problems by comparing surgery through the neck to a less invasive endoscopic approach.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT03187925

• Letrozole treatment for recurrent brain tumors

  This study is testing if letrozole, when used with another drug, can safely help people with recurrent high-grade brain tumors.

  Recruiting Early Phase 1 University of Cincinnati · Cincinnati, Ohio · NCT03122197

• Long-term safety and effectiveness of sirolimus for treating LAM

  This study is testing how safe and effective sirolimus is for people with lymphangioleiomyomatosis (LAM) over a long period of time while keeping track of their lung health and any side effects.

  Recruiting at 8 sites University of Cincinnati · Stanford, California and 19 other locations · NCT02432560

NIH-funded research (newest 40 of 366)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immune and nerve signals behind acupuncture relief for sickle cell pain

  This NIH grant explores how acupuncture helps reduce pain and opioid use for people with sickle cell disease.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11595810

• MnSOD modification drives a stem-cell like switch in some ER-positive breast cancers

  A small study in ER-positive breast cancer looks at how a specific mitochondrial change (MnSOD-K68 acetylation) may push cancer cells toward a more stem-like, therapy-resistant state.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11543353

• Lineage changes in cancer cells drive resistance to radiation and hormone therapy

  A cancer-focused study looks at how a mitochondrial enzyme modification may cause tumor cells to resist radiation and hormone therapy in prostate cancer.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11540492

• Repurposed Antiretroviral Therapies to Eliminate Cervical Cancer

  A pilot study tests a self-administered vaginal capsule with protease inhibitors to safely treat cervical precancer (CIN 2/3) in women, using a non-invasive approach.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11535226

• Recombinant factor VIIa given very early for bleeding stroke

  This trial gives a clotting medicine called rFVIIa very soon after a spontaneous brain bleed to adults to try to improve recovery.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11473255

• Early Factor VIIa treatment for bleeding stroke

  This project tests whether giving a clotting medicine called recombinant Factor VIIa very soon after a spontaneous brain bleed helps adults recover better than standard care alone.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11473147

• Early clotting-factor treatment for sudden brain bleed

  This research gives a clotting medicine called rFVIIa very soon after a sudden brain bleed to see whether people with intracerebral hemorrhage do better than with standard care alone.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11473146

• Empowering nutrition through stories for adults with IDD and their caregivers

  A community-based nutrition program designed with adults who have intellectual and developmental disabilities (IDD) and their caregivers to help them eat healthier.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11453920

• Genetic clues to fibrotic lung diseases: GENESIS Cohort

  A patient-centered study to understand inherited genetic causes of fibrotic interstitial lung diseases and lay the groundwork for future genetic-based therapies.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11453397

• Career-Enhancement Core for rare disease investigators

  A career-building program to train new researchers in rare disease and build strong ties with patient communities.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11453394

• Pilot-Feasibility Core for Rare Lung Diseases

  A funded program that supports small, patient-focused pilot studies to speed up finding better ways to diagnose and treat rare lung diseases.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11453393

• Administrative Core to accelerate rare lung disease research and share information

  A dedicated hub will organize and support rare lung disease research across clinics, patient groups, and researchers to speed up new knowledge and trials.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11453392

• Clinical readiness for rare lung diseases (RLDC)

  A group at the University of Cincinnati is building a program to speed up care for people with rare lung diseases by tracking patients over time, improving tests and treatments, and sharing information with patients and clinicians.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11453391

• PREEMIE PROGRESS: a family program to help parents of very preterm babies

  A family-centered program that teaches parents how to care for very preterm infants, offers psychosocial support, and connects families with resources to address social needs.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11453285

• New ways to cut radiation and time in kids’ PET/CT scans

  A project to dramatically reduce radiation dose and scan time for pediatric PET/CT imaging using new deep learning tools so children diagnosed with cancer (and other conditions) can stay safe during imaging.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11450391

• EMbArK: Empagliflozin for INOCA and Endothelial Health

  A study tests whether the diabetes drug empagliflozin can help people with INOCA, a type of chest pain without blocked arteries, by improving blood flow and endothelial function.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11448917

• New drugs that trigger a cancer cell stress response

  Aiming to use novel compounds to push cancer cells' internal stress system into self-destruction for people with hard-to-treat cancers.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11444784

• Leadership to expand cancer clinical trial enrollment

  A physician-leader at University of Cincinnati Cancer Center is guiding a five-year effort to enroll more patients in cancer clinical trials and speed access to experimental therapies.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11444675

• Understanding how diet and fat metabolism affect KRAS-driven cancers and ferroptosis in humans

  A study to see if specific diets and lipid strategies can slow or improve treatment of lung, pancreatic, and colorectal cancers in model systems and preclinical settings.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11444414

• Engineered metabolite nanoparticles to modulate macrophages in obesity

  Aims to use specially designed nanoparticles to rebalance inflammation in fat tissue and improve health in people with obesity.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11440598

• How lipid signals, neighborhood poverty, and small vessel disease relate to vascular cognitive impairment and dementia

  A. study will look at how blood lipid patterns, neighborhood deprivation, and small vessel brain changes relate to vascular cognitive impairment and related dementias in adults.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11433999

• Caregiver Wellness support for adults after moderate-to-severe traumatic brain injury

  A caregiver-focused program delivered by web and phone helps family members of adults with moderate-to-severe TBI feel better and support the person they care for.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11433071

• New drugs to block a cancer-driving pathway in KRAS-mutant tumors

  Scientists are making and testing novel molecules to shut down a protein pathway that helps KRAS-mutant cancers grow, with a focus on hard-to-treat cancers like pancreatic cancer.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11424752

• Environmental toxins and their effects on ovarian and heart health

  Researchers will explore how youth exposure to the environmental toxin TCDD may harm ovarian function and later heart health in females.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11423959

• CPNE5 and blood vessel leaks in sepsis-related heart failure

  This grant studies a protein called CPNE5 and how it affects blood vessel leaks that can lead to heart problems during severe infections like sepsis.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11419035

• Neuromodulators and spinal pain pathways in adults after early life injury

  This grant looks at how brain signaling chemicals change the way pain pathways in the spine strengthen signals, which could explain why people who had an injury as a child sometimes feel more pain later.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11417026

• Repurposed Antiretroviral Therapies to Eliminate Cervical Cancer (POLESA)

  A early-phase trial will test a self-administered vaginal capsule containing HIV-related protease inhibitors to treat precancerous cervical lesions in women, aiming for a non-invasive option.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11416551

• Development Core for Climate and Health Research in Appalachia and the Midwest

  This grant helps the University of Cincinnati build a cross-disciplinary program to study how climate affects health in the Appalachian region and Midwest, and to train the next generation of climate-health researchers.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11415913

• Community Engagement Core for Climate and Community Health

  A community-engaged program at the University of Cincinnati helps align research with the real needs of people in Appalachia and the Midwest to improve health during extreme weather.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11415910

• Personalized heat-risk study to protect firefighters and seniors

  A Cincinnati-area research project will look at how extreme heat affects firefighters and elderly residents, using wearable sensors and simple tests to understand who stays healthiest during heat exposure.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11415909

• Administrative Core for a Center Linking Climate and Child Health

  A centralized team will organize and support research on how extreme weather affects children and families in the Midwest and Appalachia.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11415908

• Center for Collaboration on Climate and Community Health

  A patient-facing center in Cincinnati is studying how extreme weather affects health and testing practical ways to protect people, especially kids, pregnant people, outdoor workers, and others in Appalachia and the Midwest.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11415906

• New ways to study nerve cells linked to knee osteoarthritis pain

  A researcher at a major university is exploring new models to understand how dorsal root ganglion nerves drive knee OA pain, with the aim of finding better ways to relieve pain.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11414947

• Vaginal antiviral capsule to treat cervical precancer

  This trial tests a self-inserted vaginal capsule containing the HIV drugs lopinavir/ritonavir to try to clear cervical precancer (CIN2/3) in women.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11414851

• Circadian rhythms: how our body clock keeps time and what it means for cancer

  This grant studies the body’s internal clock to understand how it affects cancer and other diseases, aiming to find ways to align our rhythms with daily life.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11412679

• How alcohol and opioids affect HIV medicines in people with HIV/AIDS

  Aims to understand how drinking alcohol and using fentanyl together change how HIV medicines work in people with HIV, which could affect treatment safety and effectiveness.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11408502

• Improving stored red blood cells for trauma care

  Aimed at making stored red blood cells safer for people who have severe bleeding from trauma.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11403782

• Organelle crosstalk and autophagosome biogenesis in human cells

  Researchers are studying how interactions between cell compartments control autophagy to better understand cancer and neurodegenerative diseases.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11402733

• Stress-Triggered RNA Breakdown in Heart Disease

  Aimed at understanding how stress changes the way heart cells break down RNA, to find new ways to prevent or treat heart disease.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11402033

• Community-driven Infant Obesity Prevention: Supporting Healthy Feeding by Addressing Moms’ Mental Health

  A community-informed program helps low-income families with infants develop healthy eating and feeding habits early, while supporting mothers’ mental health.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11400735

Quick answers

How many clinical trials run by University of Cincinnati are recruiting right now?

35, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (35 trials), Canada (1 trial), Germany (1 trial), Japan (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Early Phase 1: 3, Phase 1/2: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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