How lipid signals, neighborhood poverty, and small vessel disease relate to vascular cognitive impairment and dementia
Official title: Examining the contribution of plasma lipidomics, neighborhood deprivation and cerebral small vessel disease to vascular cognitive impairment and dementia
Funded at University of Cincinnati · NIH-11433999 · Data updated 2026-11-12
A. study will look at how blood lipid patterns, neighborhood deprivation, and small vessel brain changes relate to vascular cognitive impairment and related dementias in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 15, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $845,769 |
| NIH project number | 1R01AG104074-01 |
| Project ID | NIH-11433999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older, with a focus on older adults at risk for or with ADRD, including Black and Hispanic populations.
✕Less likely to help
Individuals without the specific risk profiles or without consent to participate in the research components may not benefit.
What this research studies
This project explores why some older adults develop vascular cognitive impairment and dementia by examining blood lipid profiles, the impact of living in deprived neighborhoods, and brain small vessel disease. Researchers will use human participants to collect data and analyze how these factors interact to influence cognitive outcomes. The study aims to identify combinations of risk factors that could explain disparities across racial groups and to inform future prevention and treatment approaches. Results could help clinicians understand which patients are at higher risk and tailor interventions accordingly.
Why it matters
Potential benefit: If successful, findings could improve risk prediction and guide personalized strategies to prevent or slow vascular cognitive impairment and related dementias.
How similar studies have gone: Previous work has shown links between vascular factors and cognitive decline, but this study integrates lipidomics, neighborhood context, and brain imaging to advance understanding.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Hyacinth, Hyacinth Idu — University of Cincinnati
- Study coordinator: Hyacinth, Hyacinth Idu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.