Understanding brain changes in children with developmental language disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates the neural mechanisms underlying grammar learning in preschoolers with developmental language disorder (DLD) using neuroimaging techniques such as functional MRI and diffusion imaging. By examining both functional and structural connectivity in the brain, the study aims to identify how treatment impacts grammar learning and the associated memory-language mechanisms. The project focuses on children aged 48-71 months who exhibit expressive grammar deficits, with the goal of informing more individualized interventions for DLD. The study will gather data before, after, and following treatment to assess changes in brain function and structure related to grammar learning.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ages 48-71 months
* average nonverbal intelligence quotient (IQ)
* enrolled in participating center
* typically developing (receptive and expressive language, social, articulation, other)
* DLD for expressive grammar
* typical oral motor function
* typical social/pragmatics skills
* average hearing thresholds
* monolingual and native Standard English speakers
* does not have any uncorrected vision challenges

Exclusion Criteria:

* receiving co-occurring speech-language or other intervention for communication
* not MRI safe
* special education placement of child based on ability or behavior

Where it's running

• Empower Learn Create INC
  Cincinnati, Ohio, United States Recruiting
• CWFF CHild Development Center
  Cincinnati, Ohio, United States Recruiting
• Wesley Education Center for Children and Families
  Cincinnati, Ohio, United States Recruiting
• University of Cincinnati
  Cincinnati, Ohio, United States Recruiting
• New Horizon Childcare
  Cincinati, Ohio, United States Not yet recruiting
• Cincinnati Children's Hospital
  Cincinnati, Ohio, United States Not yet recruiting

Study contacts

• Principal investigator: Karla N Washington, PhD — University of Cincinnati
• Study coordinator: Karla N Washington, PhD
• Email: washink2@ucmail.uc.edu
• Phone: 513-558-8533

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.