How alcohol and opioids affect HIV medicines in people with HIV/AIDS
Official title: Therapeutic and mechanistic significance of altered metabolism of HIV medicines by alcohol- or alcohol/synthetic opioid combination
Funded at University of Cincinnati · NIH-11408502 · Data updated 2026-11-12
Aims to understand how drinking alcohol and using fentanyl together change how HIV medicines work in people with HIV, which could affect treatment safety and effectiveness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 10, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $697,172 |
| NIH project number | 5R01AA030486-05 |
| Project ID | NIH-11408502 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV who are taking TAF/TDF-containing regimens and who have alcohol use or opioid exposure may be relevant for future translational steps.
✕Less likely to help
Patients with HIV not using alcohol or opioids or not on TAF/TDF-containing regimens may be less directly affected by these findings.
What this research studies
This project looks at how alcohol and fentanyl may alter how HIV drugs are processed in the body, potentially changing their safety and effectiveness. It builds on lab findings showing alcohol changes drug metabolism and even creates a new metabolite from one HIV drug. By studying these interactions, researchers hope to clarify risks for people who drink or use opioids and are on HIV therapy. The work involves examining enzymes and transporter proteins that influence drug levels and activity. If results are favorable, it could guide better dosing or safer prescribing for patients at risk.
Why it matters
Potential benefit: Better understanding of drug interactions could lead to safer HIV treatment for people who drink alcohol or use opioids.
How similar studies have gone: Preliminary studies have shown alcohol and opioids can alter HIV drug metabolism, but this program seeks to validate and extend those findings.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Yan, Bingfang — University of Cincinnati
- Study coordinator: Yan, Bingfang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.