Using brain stimulation to improve cognitive recovery in traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to explore how brain activity changes during cognitive recovery in patients with moderate to severe traumatic brain injury (TBI). It will assess the effects of anodal transcranial electrical stimulation (A-tES) on cognitive performance and brain activity during the acute phase of TBI. A total of 60 participants will be recruited, with half receiving A-tES while performing cognitive tasks and the other half receiving sham stimulation. Participants will be monitored for six months to evaluate changes in cognitive function and brain activity over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Moderate to severe TBI: Glasgow Coma Scale (GSC) in the 3-12 range and greater than 30 min of loss of consciousness and/or a post-traumatic amnesia that lasts more than 24 hours and/or an alteration of mental state over 24 hours,
2. age 18-80 years,
3. Isolated TBI,
4. Intelligible speech and Galveston Orientation and Amnesia Test (GOAT) score \>70 at time of enrollment.

Exclusion Criteria:

1. Persistent bilateral non-reactive pupils or other evidence of non-survivable injury,
2. Decompressive craniectomy to treat refractory ICP subsequent to diffuse injury, (3) Co-enrollment in another therapeutic TBI trial,

(4) Pregnancy, (5) Patients with polytrauma (6) Patients with clinical seizures or status epilepticus.

Where it's running

• University of Cincinnati
  Cincinnati, Ohio, United States Recruiting

Study contacts

• Study coordinator: Ishita Basu, PhD
• Email: basuia@ucmail.uc.edu
• Phone: 5135583991

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.