Repurposed Antiretroviral Therapies to Eliminate Cervical Cancer

Who could benefit from this research

What this research studies

This Phase 1a/1b pilot study at the University of Cincinnati will test a non-invasive, self-administered vaginal capsule containing LPV/r for CIN 2/3. Researchers will evaluate safety and how well participants accept the treatment, using escalating durations (7, 14, or 21 days) in a small group of 15 US women. The goal is to determine whether this LPV/r formulation is tolerable and shows early signs of activity against precancerous cervical changes, potentially offering a non-surgical option. The study builds on preclinical data and prior small human studies suggesting anti-cancer and anti-HPV activity of LPV/r. If promising, findings could guide larger trials and shift future care toward less invasive alternatives.

Why it matters

Where this research is happening

• University of Cincinnati
  Cincinnati, United States Active

Researchers

• Principal investigator: Pinder, Leeya F — University of Cincinnati
• Study coordinator: Pinder, Leeya F

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.