Sponsor or institution
Clinical trials and research at Seattle Inst for Biomedical/clinical Res
As of November 12, 2026, Find a Trial lists 41 NIH-funded research projects at this institution, with $28.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 41NIH research projects
NIH-funded research (newest 40 of 41)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Military Service–Linked ALS Risk in U.S. Veterans
This NIH grant investigates why U.S. veterans get ALS more often, by studying military exposures and health records to identify potential risk factors.
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Targeting MSUT2 with small molecules to slow tau-related dementia
Aims to test whether small molecules that block MSUT2’s interaction with RNA can slow or reverse tau-related brain damage in people affected by Alzheimer’s disease and related dementias.
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SPOP's role in tau-related brain disease
Researchers are studying how a protein called SPOP affects tau-related brain damage in Alzheimer's-type conditions, using a small worm model to mirror human disease and look for ways to protect brain cells.
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Comparing medicines and weight-loss surgery for liver disease linked to metabolic problems
This program looks at how two drugs and bariatric surgery work for adults with metabolic dysfunction–associated steatohepatitis (MASH) and liver fibrosis.
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Dementia with Lewy Bodies Consortium
A national research effort to better understand and diagnose Lewy body dementia by studying biomarkers and patient data over time.
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Post-TBI Sleep Problems and Alzheimer’s/CTE Brain Changes
This grant studies whether sleep disruption after a traumatic brain injury increases the risk of Alzheimer’s disease and related brain changes later on, with a focus on people who’ve had mTBI.
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Optimizing HIV care with pharmacist-driven proactive e-consults to improve lung health
A pharmacist-led program helps people with HIV get better pneumonia prevention and lung care through proactive electronic consultations.
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Mutant Tubulins and Tau: A Path toward Treatments for Alzheimer’s-Related Dementia
A scientist is studying how specific mutant tubulins may reduce harmful tau effects in brain cells, with the goal of finding ways to slow or alter Alzheimer’s-related dementia.
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Sleep disruption after mild brain injury may drive chronic post-traumatic headaches
A study of people who have had a mild traumatic brain injury to see if sleep problems help explain why headaches linger, and whether a drug called prazosin could help.
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Cholesterol's effects on insulin-producing pancreatic cells
This work looks at how cholesterol changes linked to statin use can harm insulin-making pancreatic beta cells in adults.
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How the protein NIPP1 (SUT-6) affects harmful tau in Alzheimer’s
This work will see whether the protein NIPP1 changes the harmful behavior of tau that contributes to Alzheimer's disease.
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Muscle loss in men with prostate cancer on hormone therapy
This project will follow men starting androgen deprivation (hormone) therapy for prostate cancer to track muscle loss, strength, and quality of life over 12 months.
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Molecular regulation of how the endothelial surface layer controls substance movement
This NIH grant supports research to understand how the glycocalyx on blood vessel lining cells controls how substances move between blood and tissues.
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Understanding how a protein regulates harmful tau in Alzheimer's disease
This study is looking at how a specific protein called SUT-6/NIPP1 can help reduce the harmful effects of a protein that builds up in the brains of people with Alzheimer's and similar diseases, with the hope of finding new ways to treat these conditions.
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Improving outcomes for cancer survivors with testosterone therapy
This study is looking at whether testosterone replacement therapy can help young male cancer survivors who feel tired and have other health issues due to low testosterone levels, by checking if it improves their energy, sexual health, quality of life, and physical strength.
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Understanding Brain Cells and Opioid Withdrawal
This research explores how specific brain cells called microglia contribute to the difficult experience of opioid withdrawal and the risk of relapse for individuals struggling with opioid use.
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Understanding Sleep Problems and Headaches After Mild Brain Injury
This research explores how sleep problems after a mild brain injury might lead to long-lasting headaches, hoping to find new ways to help patients.
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Understanding how certain proteins protect against Alzheimer's disease
This research explores how changes in a protein called tubulin might protect against the harmful tau protein found in Alzheimer's disease.
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Understanding how tau protein and RNA interact in Alzheimer's disease
This work explores how a protein called tau, when it binds with RNA, might cause brain changes seen in Alzheimer's disease and related conditions.
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Understanding a new pathway for type 2 diabetes treatment
This research explores how a natural body chemical might help improve both the function and number of insulin-producing cells for people with type 2 diabetes.
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Investigating the role of TDP-43 in Alzheimer's disease
This study is looking at how a protein called TDP-43, which builds up in the brains of people with Alzheimer's, interacts with other proteins and affects memory and thinking, using special tests and brain scans to see how it all works.
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How cholesterol affects insulin-producing cells in the pancreas
This study is looking at how cholesterol and statin medications might affect the health of insulin-producing cells in the pancreas, which is important for people taking statins to help prevent type 2 diabetes.
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Mutant tubulins may help reduce tau-related damage in Alzheimer's disease.
This study is looking at how certain changes in tubulin proteins might help protect brain cells from damage caused by tau, a protein linked to Alzheimer's and similar diseases, using tiny worms and brain cells to find new ways to treat these conditions.
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Investigating how circulating microRNAs can predict treatment response in type 2 diabetes.
This study is looking at why some people with type 2 diabetes don’t respond well to treatments that help their insulin work better, and it aims to find certain markers in the blood that could help doctors figure out which treatments might work best for each patient.
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Investigating how astrocytes contribute to Alzheimer's disease
This study is looking at how certain brain cells called astrocytes help manage a chemical linked to Alzheimer's disease, and it hopes to find new ways to support brain health for people living with this condition.
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Understanding muscle loss in men with prostate cancer receiving hormone therapy
This study is looking at how losing muscle mass and strength affects men with advanced prostate cancer who are receiving hormone therapy, and it aims to find ways to better support these patients over the next year.
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Understanding how lipid metabolism affects protein aggregation in neurodegenerative diseases
This study is looking at how a specific gene mutation related to Parkinson's disease affects fat processing in the body and how this might speed up the spread of harmful proteins in the brain, using fruit flies, mice, and human cells to help find new ways to treat neurodegenerative diseases.
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How tau protein interactions with RNA affect Alzheimer's disease
This study is looking at how certain connections between tau protein and RNA might affect brain health and contribute to Alzheimer's disease, with the hope of finding new ways to understand and treat the condition.
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Helping veterans with HIV quit smoking
This study is testing a new program called WISH that helps veterans with HIV quit smoking and improve their overall health using friendly text and voice messages on their phones, making it easy and supportive for everyone, no matter where they are in their quitting journey.
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Understanding and improving movement in patients with stiff big toes
This study is looking at ways to improve movement in the big toe joint for people with hallux rigidus, aiming to create new implants that help you move better and live pain-free without the issues that come with current surgeries.
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Using wearable sensors to help diagnose dementia with Lewy bodies earlier
This study is looking at how using wearable sensors alongside regular check-ups can help doctors spot dementia with Lewy bodies earlier, especially since it can look a lot like Alzheimer's, and it's for anyone who wants to help improve the way we diagnose and treat these conditions.
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Understanding how brain cells affect opioid withdrawal and relapse
This study is looking at how certain brain cells called microglia might affect the feelings and challenges people face when they stop using opioids, with the hope of finding better ways to help those recovering from addiction.
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Investigating how sleep disruption after mild traumatic brain injury affects chronic headaches.
This study is looking at how sleep problems might be linked to chronic headaches that some people get after a mild brain injury, and it will test if a medication called prazosin can help improve sleep and reduce headache pain.
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Improving fatigue and quality of life in older men with cancer and low testosterone
This study is looking at how testosterone replacement therapy might help older men with cancer feel less tired, improve their sex life, and boost their overall quality of life.
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Sleep problems after concussion and links to Alzheimer's and CTE
Researchers are looking at whether sleep problems after a concussion lead to Alzheimer’s-related brain changes in people who had mild traumatic brain injury.
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Understanding how tau protein contributes to Alzheimer's disease
This study is looking at how a harmful protein called tau affects brain cells in Alzheimer's disease and is testing ways to help protect those cells by activating a natural response in the body, which could lead to new treatments for people with Alzheimer's and related conditions.
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Exploring how Tai Chi may improve brain waste clearance and sleep in older adults.
This study is looking at how practicing Tai Chi might help older adults at risk for Alzheimer's by improving their sleep and helping their brains clear out waste, which could be a step towards preventing or slowing down Alzheimer's symptoms.
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Developing small molecules to target tau pathology in Alzheimer's disease
This study is looking for new medicines that can help fight Alzheimer's disease by targeting a specific protein called MSUT2, which is linked to the harmful buildup of tau in the brain, and it’s for anyone interested in finding better treatments for this condition.
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Understanding how tau protein causes neurodegeneration in Alzheimer's disease
This study is looking at how a protein called tau affects brain cells in Alzheimer's and similar diseases, using tiny worms to learn more about the problem and find new ways to help people with these conditions.
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Choosing the right surgery for severe big toe arthritis
This study is looking to learn more about two different types of surgeries for people with hallux rigidus, a condition that affects the big toe, so that patients and doctors can make better choices about treatment options that could improve their quality of life.
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