Dementia with Lewy Bodies Consortium
Funded at Seattle Inst for Biomedical/clinical Res · NIH-11412709 · Data updated 2026-11-12
A national research effort to better understand and diagnose Lewy body dementia by studying biomarkers and patient data over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,589,638 |
| NIH project number | 5U01NS100610-10 |
| Project ID | NIH-11412709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with Lewy body dementia or Parkinson’s disease with dementia who can participate in biomarker collection and longitudinal follow-up.
✕Less likely to help
Participants with conditions outside Lewy body dementia or those unable to complete follow-up may see limited benefit.
What this research studies
This project brings multiple research centers together to study Lewy body dementia, including dementia with Lewy bodies and Parkinson’s disease with dementia. Researchers will collect and compare biofluid biomarkers and other patient information to understand how Lewy body and Alzheimer’s pathologies relate to symptoms. The study emphasizes standardized approaches and longitudinal follow-up, including autopsy data when available, to improve diagnostic accuracy. The goal is to create clearer criteria and biomarkers that help clinicians diagnose and manage LBD.
Why it matters
Potential benefit: If successful, patients may receive more accurate diagnoses and better-tailored treatments for Lewy body dementia.
How similar studies have gone: Previous large consortiums in Alzheimer’s and Parkinson’s research showed that standardized, multi-center biomarker studies can improve diagnosis and understanding of disease.
Where this research is happening
-
Seattle Inst for Biomedical/clinical Res
Seattle, United States Active
Researchers
- Principal investigator: Leverenz, James Bruce — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Leverenz, James Bruce
Related research
Other NIH-funded projects on the same topics.
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Understanding how heparan sulfate affects alpha-synuclein in Lewy body dementia
A small study in people who have dementia with Lewy bodies looks at how a brain sugar (heparan sulfate) helps a harmful protein (alpha-synuclein) spread, with the hope of slowing disease progression.
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Alpha-synuclein seed test in blood or urine for Parkinson’s and Lewy body diseases
A new blood or urine test using seed amplification to help diagnose Parkinson’s disease, dementia with Lewy bodies, and related conditions earlier and more clearly.
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Rat model of dementia with Lewy bodies may help us study memory and movement problems
A scientist team is creating and validating a rat model that mirrors Dementia with Lewy Bodies to better understand how it develops and to test potential treatments.
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Proof of Concept Study on Clinical Trial Outcomes and Biomarkers in Early Lewy Body Dementia
A small, early-stage study is testing whether new biomarkers and trial outcomes can better measure symptoms and treatment effects for people with Lewy body dementia.
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Amyloid-clearing therapy for dementia with Lewy bodies plus Alzheimer's disease
A study tests an amyloid-clearing antibody in people who have both Dementia with Lewy bodies and Alzheimer's disease to see if it can safely help with their symptoms.
-
New method to deliver treatments for dementia with Lewy bodies
This study is exploring a new way to deliver special treatments that can help reduce harmful proteins linked to dementia, using a friendly peptide to help get these treatments into the brain more easily, with the goal of making therapies safer and more effective for people with dementia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.