Investigating how astrocytes contribute to Alzheimer's disease
Role of Astrocyte EAAT2/GLT1 Failure in Alzheimer's Disease Pathogenesis
['FUNDING_R01'] · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · NIH-11012806
This study is looking at how certain brain cells called astrocytes help manage a chemical linked to Alzheimer's disease, and it hopes to find new ways to support brain health for people living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE INST FOR BIOMEDICAL/CLINICAL RES (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11012806 on ClinicalTrials.gov |
What this research studies
This research focuses on the role of astrocytes, a type of brain cell, in Alzheimer's disease (AD). It examines how these cells help clear glutamate, a neurotransmitter, from the brain and how their dysfunction may contribute to the progression of AD. The study utilizes mouse models to explore the relationship between astrocytic glutamate transporters and the pathological features of AD, such as amyloid-beta and tau proteins. By understanding these interactions, the research aims to uncover potential therapeutic targets for improving brain health in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE INST FOR BIOMEDICAL/CLINICAL RES — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COOK, DAVID G — SEATTLE INST FOR BIOMEDICAL/CLINICAL RES
- Study coordinator: COOK, DAVID G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.