Investigating how astrocytes contribute to Alzheimer's disease
Official title: Role of Astrocyte EAAT2/GLT1 Failure in Alzheimer's Disease Pathogenesis
Funded at Seattle Inst for Biomedical/clinical Res · NIH-11012806 · Data updated 2026-11-12
This study is looking at how certain brain cells called astrocytes help manage a chemical linked to Alzheimer's disease, and it hopes to find new ways to support brain health for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $643,846 |
| NIH project number | 5R01AG075338-04 |
| Project ID | NIH-11012806 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on the role of astrocytes, a type of brain cell, in Alzheimer's disease (AD). It examines how these cells help clear glutamate, a neurotransmitter, from the brain and how their dysfunction may contribute to the progression of AD. The study utilizes mouse models to explore the relationship between astrocytic glutamate transporters and the pathological features of AD, such as amyloid-beta and tau proteins. By understanding these interactions, the research aims to uncover potential therapeutic targets for improving brain health in Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain function and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of astrocytes in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Seattle Inst for Biomedical/clinical Res
Seattle, United States Active
Researchers
- Principal investigator: Cook, David G — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Cook, David G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.