How cholesterol affects insulin-producing cells in the pancreas
Official title: Effects of Cholesterol in Pancreatic Islets
Funded at Seattle Inst for Biomedical/clinical Res · NIH-11064796 · Data updated 2026-11-12
This study is looking at how cholesterol and statin medications might affect the health of insulin-producing cells in the pancreas, which is important for people taking statins to help prevent type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $387,718 |
| NIH project number | 5R01DK134502-03 |
| Project ID | NIH-11064796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who are currently taking statins and are at risk of developing type 2 diabetes.
✕Less likely to help
Patients who are not on statin therapy or those who do not have risk factors for type 2 diabetes may not benefit from this research.
What this research studies
This research investigates the impact of cholesterol, particularly in the context of statin use, on the function and survival of insulin-producing beta cells in the pancreas. The study aims to uncover the mechanisms by which statins may lead to the deterioration of these cells, which is crucial for preventing the onset of type 2 diabetes in patients taking these medications. By focusing on cholesterol transport to mitochondria and its metabolism, the research seeks to fill a significant knowledge gap regarding beta cell health. The findings could lead to new strategies to protect these cells and improve outcomes for patients on statin therapy.
Why it matters
Potential benefit: If successful, this research could help develop strategies to prevent type 2 diabetes in patients using statins.
How similar studies have gone: While the specific mechanisms being studied are less explored, there is existing literature indicating that cholesterol management is critical for beta cell function, suggesting potential for success in this area.
Where this research is happening
-
Seattle Inst for Biomedical/clinical Res
Seattle, United States Active
Researchers
- Principal investigator: Zraika, Sakeneh — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Zraika, Sakeneh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.