Post-TBI Sleep Problems and Alzheimer’s/CTE Brain Changes
Official title: Defining the Role of Post-TBI Sleep Disruption in the Development of CTE and Alzheimer's Disease-Related Neuropathology
Funded at Seattle Inst for Biomedical/clinical Res · NIH-11397349 · Data updated 2026-11-12
This grant studies whether sleep disruption after a traumatic brain injury increases the risk of Alzheimer’s disease and related brain changes later on, with a focus on people who’ve had mTBI.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 20, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,273,207 |
| NIH project number | 5R01NS128966-03 |
| Project ID | NIH-11397349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of mild traumatic brain injury, especially those long after the injury and experiencing sleep disturbances.
✕Less likely to help
People without a history of traumatic brain injury or sleep problems may not directly benefit from this research.
What this research studies
If you’ve had a concussion, this research looks at how ongoing sleep problems might influence the brain changes linked to Alzheimer’s disease and chronic traumatic encephalopathy. The team will look at biomarkers in cerebrospinal fluid, special MRI markers, and sleep patterns to understand the connection. By following patients with a history of mTBI, researchers hope to identify whether improving sleep could reduce later brain changes associated with these conditions. The study combines clinical observations with advanced imaging and biomarker analysis to map the sleep-brain pathology pathway. Results could guide future interventions to protect brain health after injury.
Why it matters
Potential benefit: If successful, the work could lead to sleep-focused strategies to lower the risk of Alzheimer’s-related pathology after brain injury.
How similar studies have gone: Prior data suggest a link between sleep disturbance and Alzheimer’s-related biomarkers, but this project tests the mechanism in post-TBI populations.
Where this research is happening
-
Seattle Inst for Biomedical/clinical Res
Seattle, United States Active
Researchers
- Principal investigator: Peskind, Elaine R. — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Peskind, Elaine R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.