How tau protein interactions with RNA affect Alzheimer's disease
Official title: Formation of Tau RNA Complexes disrupts tau function and drives tau neuropathology
Funded at Seattle Inst for Biomedical/clinical Res · NIH-10936528 · Data updated 2026-11-12
This study is looking at how certain connections between tau protein and RNA might affect brain health and contribute to Alzheimer's disease, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 30, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $647,228 |
| NIH project number | 5R01AG084680-02 |
| Project ID | NIH-10936528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who may benefit from novel treatment approaches targeting tau pathology.
✕Less likely to help
Patients with non-tau related forms of dementia or those without a diagnosis of Alzheimer's disease may not receive benefit from this research.
What this research studies
This research investigates how the formation of tau RNA complexes influences the function of tau protein and contributes to the progression of Alzheimer's disease. By examining the molecular interactions between tau and RNA, the study aims to understand how these complexes may lead to neurodegeneration. The researchers will utilize advanced techniques to analyze the characteristics of tau RNA binding and its effects on neuronal health, potentially revealing new pathways involved in Alzheimer's pathology.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting tau RNA complexes to slow or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding tau protein interactions, suggesting that this approach may lead to significant advancements in Alzheimer's disease treatment.
Where this research is happening
-
Seattle Inst for Biomedical/clinical Res
Seattle, United States Active
Researchers
- Principal investigator: Kraemer, Brian C. — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Kraemer, Brian C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.