Understanding a new pathway for type 2 diabetes treatment
Role of the Renin-Angiotensin System in Glucose Homeostasis
['FUNDING_R01'] · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · NIH-11123112
This research explores how a natural body chemical might help improve both the function and number of insulin-producing cells for people with type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE INST FOR BIOMEDICAL/CLINICAL RES (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11123112 on ClinicalTrials.gov |
What this research studies
We are looking into how a substance called angiotensin(1-7), which is part of your body's natural system, could help manage type 2 diabetes. Our findings suggest that a smaller piece of this substance, angiotensin(1-2), might improve how your body makes insulin and also help preserve or increase the cells that produce insulin. This work aims to uncover the exact ways angiotensin(1-2) works within the body, specifically focusing on its effects on insulin-producing cells and other related cells in the pancreas. By understanding these mechanisms, we hope to find new and more effective ways to treat type 2 diabetes.
Who could benefit from this research
Good fit: This foundational research is for adults with type 2 diabetes, as it focuses on understanding the underlying biological mechanisms of the disease.
Not a fit: Patients without type 2 diabetes or those with other forms of diabetes may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this research could lead to new medications for type 2 diabetes that not only help insulin-producing cells work better but also increase their numbers.
How similar studies have performed: While the broader renin-angiotensin system is known, this specific pathway involving angiotensin(1-2) and its dual action on beta-cell function and mass is a novel area of investigation.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE INST FOR BIOMEDICAL/CLINICAL RES — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZRAIKA, SAKENEH — SEATTLE INST FOR BIOMEDICAL/CLINICAL RES
- Study coordinator: ZRAIKA, SAKENEH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus