Investigating the role of TDP-43 in Alzheimer's disease
TDP-43 in Alzheimer's disease
This study is looking at how a protein called TDP-43, which builds up in the brains of people with Alzheimer's, interacts with other proteins and affects memory and thinking, using special tests and brain scans to see how it all works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11091529 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of TDP-43, a protein that aggregates in the brains of Alzheimer's disease patients, and its interaction with other proteins like tau. By using advanced models, the researchers aim to explore how TDP-43 contributes to the progression of Alzheimer's and its impact on cognitive decline. The study will involve behavioral assessments and neuroimaging to observe changes in brain function and structure. Additionally, RNA sequencing will be utilized to analyze gene expression related to these proteins.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who may also exhibit TDP-43 pathology.
Not a fit: Patients with Alzheimer's disease who do not show TDP-43 aggregates may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and potential therapeutic targets.
How similar studies have performed: Previous research has indicated that understanding the interactions of TDP-43 with other proteins in neurodegenerative diseases could lead to significant advancements in treatment strategies.
Where this research is happening
Seattle, United States
- Seattle Inst for Biomedical/clinical Res — Seattle, United States (Active)
Researchers
- Principal investigator: Liachko, Nicole Faron — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Liachko, Nicole Faron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.