Investigating how circulating microRNAs can predict treatment response in type 2 diabetes.
Official title: Circulating miRNAs and prediction of beta-cell treatment response: The Restoring Insulin Secretion Study
Funded at Seattle Inst for Biomedical/clinical Res · NIH-11034129 · Data updated 2026-11-12
This study is looking at why some people with type 2 diabetes don’t respond well to treatments that help their insulin work better, and it aims to find certain markers in the blood that could help doctors figure out which treatments might work best for each patient.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 20, 2022 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $461,835 |
| NIH project number | 5R01DK132355-04 |
| Project ID | NIH-11034129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with type 2 diabetes who are undergoing treatment.
✕Less likely to help
Patients with type 1 diabetes or those who do not have type 2 diabetes may not benefit from this research.
What this research studies
This research focuses on understanding why some patients with type 2 diabetes do not respond to treatments aimed at improving insulin secretion. By analyzing data from a previous study, the researchers aim to identify circulating microRNAs that could serve as biomarkers to predict which patients will benefit from specific treatments. The study will involve measuring these microRNAs in patients' blood and correlating them with treatment outcomes, potentially leading to more personalized diabetes care.
Why it matters
Potential benefit: If successful, this research could enable more effective and tailored treatment strategies for individuals with type 2 diabetes.
How similar studies have gone: Previous studies have shown promise in using biomarkers for predicting treatment responses in diabetes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Seattle Inst for Biomedical/clinical Res
Seattle, United States Active
Researchers
- Principal investigator: Januszewski, Pandora Luke — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Januszewski, Pandora Luke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.