Molecular regulation of how the endothelial surface layer controls substance movement
Official title: Molecular regulation of endothelial glycocalyx-mediated transcytosis
Funded at Seattle Inst for Biomedical/clinical Res · NIH-11258364 · Data updated 2026-11-12
This NIH grant supports research to understand how the glycocalyx on blood vessel lining cells controls how substances move between blood and tissues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 1, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $374,550 |
| NIH project number | 1R35GM161201-01 |
| Project ID | NIH-11258364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient enrollment in this grant, but findings may inform future therapies affecting vascular transport.
✕Less likely to help
This grant does not involve recruiting patients directly.
What this research studies
Researchers will study the glycocalyx, the carbohydrate-rich surface on endothelial cells, to learn how it binds and transports proteins and other molecules across blood vessel walls. They will use radiochemical assays to measure how quickly things move from blood to tissue in living systems and in cell-based models. The aim is to map tissue- and vessel-specific differences in transport and identify the molecular machinery behind glycocalyx-mediated transendothelial transport. The work builds on five years of prior findings and seeks to reveal new targets to influence drug delivery and tissue communication via the endothelium.
Why it matters
Potential benefit: Better understanding of how drugs and natural substances travel from blood into tissues could lead to more precise delivery and fewer side effects.
How similar studies have gone: Prior work has shown tissue-specific differences in glycocalyx-mediated transport and successful use of radiochemical tools to measure transport parameters.
Where this research is happening
-
Seattle Inst for Biomedical/clinical Res
Seattle, United States Active
Researchers
- Principal investigator: Erickson, Michelle a. — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Erickson, Michelle a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.