Condition

Cerebral Small Vessel Diseases clinical trials and research

• 18Clinical trials
• 1NIH research projects
• 7Countries

Newest Cerebral Small Vessel Diseases clinical trials

All recruiting trials (18)

• Can QSM MRI help tell MS from age-related brain changes in older adults

  This study tests whether an advanced MRI technique called QSM can better differentiate MS-related brain lesions from age-related or small vessel changes in people aged 50–70.

  Recruiting Oslo University Hospital · Oslo, Oslo · NCT07444047

• Registry for people with cerebral small vessel disease.

  This project will collect clinical information and MRI scans from people aged 50 and older with MRI signs of cerebral small vessel disease to see how the condition relates to thinking, walking, and daily function over time.

  Recruiting Dongzhimen Hospital, Beijing · Beijing, Beijing Municipality · NCT07342075

• Observing brain blood vessel health in a community

  This study looks at how blood vessel health in the brain is affected by conditions like high blood pressure and diabetes in adults aged 50-75 living in Beijing.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06579677

• Intermittent theta-burst brain stimulation to improve thinking in people with small vessel brain disease

  This trial will try intermittent theta-burst stimulation (a form of noninvasive brain stimulation) to see if it helps cognition in people aged 45–80 with vascular cognitive impairment from cerebral small vessel disease.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT06579664

• Evaluating the effects of Calculus Bovis Sativus for ischemic cerebrovascular diseases

  This study is testing whether a traditional Chinese medicine called Calculus Bovis Sativus can help improve brain health and reduce inflammation in people with ischemic cerebrovascular diseases like stroke.

  Recruiting at 2 sites Tongji Hospital · Wuhan, Hubei and 1 other locations · NCT06474507

• Evaluating retinal health in patients with cerebral small vessel disease

  This study is testing if a special eye scan can help doctors understand how brain health is affected in older adults with cerebral small vessel disease.

  Recruiting Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06431711

• Investigating retinal vessel leakage in cerebral small vessel disease

  This study is trying to see if leaking blood vessels in the eyes can help us understand how serious cerebral small vessel disease is in people who have had mild strokes.

  Recruiting University of Edinburgh · Edinburgh · NCT06416371

• Registry for young and middle-aged patients with cerebral small vessel diseases and dementia risk

  This study is trying to see how small blood vessel problems in the brain affect thinking skills in younger adults aged 30 to 60 who don’t have dementia yet.

  Recruiting Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06164262

• Effect of revascularization on small vessel disease in carotid artery stenosis

  This study is testing if a procedure to improve blood flow in the carotid artery can help prevent brain and eye problems in people with narrowed arteries.

  Recruiting Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06031610

• Investigating the relationship between white matter hyperintensity shape and brain clearance in dementia

  This study is trying to see how the shape of certain brain changes in older adults with small vessel disease relates to their thinking skills and dementia.

  Recruiting Leiden University Medical Center · Leiden · NCT06010511

• Observing patients with cerebral small vessel disease

  This study looks at patients with cerebral small vessel disease to gather information about their health and brain scans to better understand the condition and find ways to predict mood and thinking problems.

  Recruiting Shanghai Yueyang Integrated Medicine Hospital · Shanghai · NCT05985213

• Exploring the relationship between large artery atherosclerosis and small vessel disease in the brain

  This study looks at how large artery blockages and small blood vessel problems in the brain affect each other and worsen conditions like stroke and dementia, using MRI to find ways to prevent and treat these issues better.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT05677607

• Investigating genetic and non-genetic factors in small vessel disease

  This study is trying to see how genetic and non-genetic factors affect people with small vessel disease in the brain by looking at their symptoms and MRI results over two years.

  Recruiting National Taiwan University Hospital · Taipei · NCT05473637

• Fighting cognitive decline and dementia caused by small vessel disease

  This study is trying to see how changes in the brain and eye blood vessels can help predict dementia risk in people over 60 with small vessel disease.

  Recruiting at 2 sites University Hospital, Bordeaux · Bordeaux and 1 other locations · NCT05306834

• National imaging platform for cerebral small vessel diseases

  This study is trying to create a new platform to collect and analyze brain scans and other health data from people with cerebral small vessel diseases to better understand the condition and find ways to identify those at higher risk.

  Recruiting Peking University Third Hospital · Beijing · NCT04962295

• Using retinal health to assess brain blood vessel conditions

  This study is testing if changes in the eye can help track brain blood vessel problems and whether a medication called cilostazol can slow down these issues in people with certain types of brain diseases.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT04753970

• Registry for Cerebral Small Vessel Disease

  This study is looking at how Cerebral Small Vessel Disease affects people over time and what factors might help doctors manage it better.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT04318119

• Exploring cognitive impairment and eye health in elderly individuals

  This study looks at how brain and eye health are connected in older adults with small vessel disease to see if certain changes can predict memory problems in the future.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT03542734

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating inflammation and blood vessel changes in brain diseases related to aging

  This study is looking at how inflammation and changes in blood vessels can cause bleeding in the brain, especially for people with conditions like cerebral amyloid angiopathy and arteriolosclerosis, to find new ways to help prevent these dangerous issues.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10861499

Related topics

Quick answers

How many Cerebral Small Vessel Diseases clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (12 trials), United Kingdom (1 trial), Norway (1 trial), United States (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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