Investigating how sex affects brain health in Alzheimer's and vascular dementia.

Who could benefit from this research

What this research studies

This research focuses on understanding the impact of sex on white matter integrity and brain function in individuals with familial Alzheimer's disease and vascular dementia. By examining the effects of cerebral small vessel disease, the study aims to identify how vascular impairments contribute to cognitive decline and the accumulation of amyloid-beta protein in the brain. The research utilizes hereditary models of these conditions to explore potential diagnostic and therapeutic strategies that could be applied to more common forms of dementia. Early detection and intervention are key goals, as they may improve outcomes for affected individuals.

Why it matters

Where this research is happening

• Boston University (Charles River Campus)
  Boston, United States Active

Researchers

• Principal investigator: Giudicessi, Averi Jordin — Boston University (Charles River Campus)
• Study coordinator: Giudicessi, Averi Jordin

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.