Improving early diagnosis of dementia in primary care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the diagnostic accuracy of Alzheimer's disease and cognitive impairment in primary care settings. It focuses on recruiting diverse patients with subjective cognitive decline, mild cognitive impairment, and mild dementia. The study will evaluate cognitive tests, blood-based biomarkers, and brain imaging methods to facilitate early diagnosis and improve patient management. By comparing traditional and novel cognitive screening tools, the study seeks to identify the most effective methods for early detection in primary care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. The patient seeks medical help because of cognitive symptoms experienced by the patient and/or informant OR The general practitioner suspects a progressive neurodegenerative disorder including, but not limited to, Alzheimer's disease, Lewy body disease, frontotemporal lobar degeneration or subcortical vascular cognitive impairment.
2. The main symptom is usually memory complaints, but could also be executive, visuo-spatial, language, or attention complaints.
3. Age ≥40 years
4. Subjective cognitive decline, mild cognitive impairment or mild dementia

Exclusion Criteria:

1. Already diagnosed dementia
2. Significant unstable systemic illness or organ failure that makes it difficult to participate.
3. Current significant alcohol or substance misuse.
4. Refusing investigation at the Memory clinic
5. Cognitive impairment with acute onset due to stroke
6. The cognitive impairment can with certainty be explained by another condition or disease such as significant anemia, infection, severe sleep deprivation, psychotic disorder, moderate-severe depression, alcohol abuse etc.

Where it's running

• Primary care centers in Region Skåne
  Malmö, Sweden Recruiting

Study contacts

• Principal investigator: Erik Stomrud, MD, PhD — Skane University Hospital and Lund University
• Study coordinator: Sebastian Palmqvist, MD, PhD
• Email: Sebastian.Palmqvist@med.lu.se
• Phone: +46-40-331000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Investigating new blood tests for diagnosing memory disorders

  This study is testing new blood tests to see if they can help diagnose memory disorders like mild dementia and Alzheimer's better than the current method that uses spinal fluid.

  Recruiting Skane University Hospital · Malmö · NCT06122415

• Using brain stimulation and digital training to improve cognitive function in older adults

  This study is testing whether a combination of brain stimulation and digital training can help improve thinking skills in older adults with Mild Cognitive Impairment and Alzheimer's Disease.

  Recruiting Universidade Federal do Rio de Janeiro · Rio de Janeiro, Rio de Janeiro · NCT06733714

• A study on early diagnosis and biomarkers for dementia and related diseases

  This study is testing new ways to spot dementia and related diseases early by looking for specific markers in the brain and body, to help people at high risk and track how well new treatments are working.

  Recruiting at 2 sites Skane University Hospital · Ängelholm and 1 other locations · NCT03174938

• Hyperspectral retinal imaging to detect Alzheimer’s and other neurodegenerative changes

  This project will test whether a special retinal camera that scans many wavelengths of light can detect signs of Alzheimer’s and other neurodegenerative diseases in people with dementia or at risk.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07545473

• Predicting disease progression in dementia using biomarkers and modeling

  This study is trying to create a tool that helps predict how dementia will progress in people with mild cognitive impairment and different types of dementia, like Alzheimer's and Lewy Body Disease, by looking at brain scans, body fluids, and mental tests.

  Recruiting University Health Network, Toronto · North York, Ontario and 3 other locations · NCT06529744

• Effects of social isolation and interaction on dementia risk in people with subjective cognitive decline

  This study is trying to see how being socially isolated or interacting with others affects the risk of dementia in people who notice early signs of memory problems.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, China, Jiangsu · NCT06335836

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.