Investigating retinal vessel leakage in cerebral small vessel disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the occurrence of leakage from retinal vessels in patients with cerebral small vessel disease (SVD). Using fluorescein angiography, participants will be assessed for retinal vessel leakage, which may correlate with the severity of their SVD. The study will recruit individuals from the Mild Stroke Study 3 cohort who have previously undergone brain scans and other evaluations. The findings could provide insights into the pathogenesis of SVD and offer a cost-effective alternative to MRI for monitoring disease progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Membership in the Mild Stroke Study 3 cohort
* Contrast enhanced MRI within 12 months
* Clear optical media in both eyes, as assessed by study investigator
* Best corrected visual acuity (near vision) ≥N36

Exclusion Criteria:

* Any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension)
* Previous treatment for retinal leakage (retinal laser, intravitreal anti-VEGF)
* Recent eye surgery
* Shallow anterior chambers as assessed by torch test
* Pregnancy, renal failure
* Severe dementia
* Known allergy to fluorescein
* History of allergy such as food or drug induced urticaria or history of bronchial asthma
* Any other severe or acute medical or psychiatric conditions
* Inability to give informed consent

Where it's running

• NHS Lothian
  Edinburgh, United Kingdom Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Digital Dementia Registry Bavaria: a multicenter, long-term registry of people with mild cognitive impairment and dementia and their family caregivers

  This registry will collect long-term health and care data from people with mild cognitive impairment or dementia in Bavaria and their caregivers to understand how dementia progresses and how care is provided.

  Recruiting at 12 sites University of Erlangen-Nürnberg Medical School · Aschaffenburg and 11 other locations · NCT07721701

• Hyperspectral retinal imaging to detect Alzheimer’s and other neurodegenerative changes

  This project will test whether a special retinal camera that scans many wavelengths of light can detect signs of Alzheimer’s and other neurodegenerative diseases in people with dementia or at risk.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07545473

• Can QSM MRI help tell MS from age-related brain changes in older adults

  This study tests whether an advanced MRI technique called QSM can better differentiate MS-related brain lesions from age-related or small vessel changes in people aged 50–70.

  Recruiting Oslo University Hospital · Oslo, Oslo · NCT07444047

• Polyphenol-rich Salicornia plus B vitamins to slow cognitive decline after lacunar stroke

  This will test whether a Salicornia-derived polyphenol supplement combined with B vitamins can slow thinking and memory decline in people who had a lacunar stroke within the past year.

  Recruiting Fundación Pública Andaluza para la gestión de la Investigación en Sevilla · Seville · NCT07353424

• Registry for people with cerebral small vessel disease.

  This project will collect clinical information and MRI scans from people aged 50 and older with MRI signs of cerebral small vessel disease to see how the condition relates to thinking, walking, and daily function over time.

  Recruiting Dongzhimen Hospital, Beijing · Beijing, Beijing Municipality · NCT07342075

• What predicts emergency department visits in frail older adults

  This project tests whether a blood marker (plasma pTau181) and signs of cerebrovascular damage can help predict which non-autonomous older adults will need to return to the emergency department within six months.

  Recruiting University of Pisa · Pisa, Pisa · NCT07259499

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.