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Total Knee Replacement Surgery clinical trials and research
As of November 12, 2026, Find a Trial lists 4 Total Knee Replacement Surgery clinical trials that are recruiting, at sites in 3 countries (most in United States (2), United Kingdom (1), Belgium (1)). By phase: Phase 3 (2). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 3Countries
Newest Total Knee Replacement Surgery clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Suzetrigine for pain relief after knee replacement | Phase 3 | New York, New York | Recruiting | Oct 8, 2026 |
| Suzetrigine to reduce pain after total knee replacement | Phase 3 | New York, New York | Recruiting | Apr 23, 2026 |
| Robotic Mako cementless versus cemented total knee replacement | — | London | Recruiting | Apr 16, 2025 |
| Comparing robotic and augmented reality techniques for knee replacement surgery | — | Sint-Martens-Latem, Oost-Vlaanderen | Recruiting | Mar 24, 2025 |
All recruiting trials (4)
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Suzetrigine for pain relief after knee replacement
This trial tests whether suzetrigine can reduce opioid use after a total knee replacement compared with placebo.
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Suzetrigine to reduce pain after total knee replacement
This trial tests whether giving Suzetrigine before surgery helps adults having total knee replacement use fewer opioids and have less postoperative pain.
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Robotic Mako cementless versus cemented total knee replacement
This study will test whether robotic Mako cementless or cemented knee replacements work better for adults having a primary total knee replacement for osteoarthritis.
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Comparing robotic and augmented reality techniques for knee replacement surgery
This study is testing whether using robotic tools or augmented reality can help doctors place knee replacement parts more accurately for patients with severe knee arthritis.
Related topics
Quick answers
How many Total Knee Replacement Surgery clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (2 trials), United Kingdom (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.