Improving Function and Pain After Total Knee Replacement Through Physical Activity and Weight Loss
Official title: Physical Activity and Weight Loss to Improve Function and Pain after Total Knee Replacement
Funded at University of South Carolina at Columbia · NIH-11144577 · Data updated 2026-11-12
This program helps adults who have had total knee replacement surgery improve their movement and reduce pain by focusing on physical activity and healthy weight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | July 15, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $476,464 |
| NIH project number | 5R01AG070004-05 |
| Project ID | NIH-11144577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults aged 21 and older who have recently undergone total knee replacement surgery and are overweight or obese.
✕Less likely to help
Patients who are not overweight or obese, or who have not had total knee replacement surgery, may not directly benefit from this specific program.
What this research studies
Many people who have total knee replacement surgery still struggle with movement and pain, and often gain weight afterward. This program offers a personalized approach to help you manage your weight and increase your physical activity after surgery. Participants will join either a patient-centered weight loss program, which is designed to fit your unique needs and challenges, or a group focused on managing chronic diseases. The goal is to help you move better, feel less pain, and improve your overall health and independence in the long term.
Why it matters
Potential benefit: If successful, this program could help patients recover better after total knee replacement, leading to less pain, improved movement, and a higher quality of life.
How similar studies have gone: While the benefits of physical activity and weight management for overall health are well-known, this specific patient-centered program is being tested in a rigorous trial to confirm its effectiveness after total knee replacement.
Where this research is happening
-
University of South Carolina at Columbia
Columbia, United States Active
Researchers
- Principal investigator: Pellegrini, Christine Ann — University of South Carolina at Columbia
- Study coordinator: Pellegrini, Christine Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.