Remote exercise program for people with knee replacements

Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement

NIH-funded research University of South Carolina at Columbia · NIH-11170525

Different online program features will be tried to help adults who had a total knee replacement become more active.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of South Carolina at Columbia NIH-funded
Lab location1 site (Columbia, United States)
Project IDNIH-11170525 on NIH RePORTER

What this research studies

You would join a 6-month, fully automated online program called Energize! that helps you plan and report daily exercise, watch brief behavioral videos, and get automated feedback. The study enrolls adults at least 12 months after total knee replacement and uses activity trackers (accelerometers) to measure movement. Using the Multiphase Optimization Strategy (MOST), participants are randomized to receive different additional program components so researchers can find the most effective, scalable combination. Participation is remote and nationwide, so you can take part from home if you have internet access and can wear the activity tracker.

Who could benefit from this research

Good fit: Adults at least 12 months after total knee replacement who can use the internet and wear an activity tracker are ideal candidates.

Not a fit: People less than 12 months after surgery, those without reliable internet or mailing addresses, or those who cannot safely increase activity due to other medical conditions may not benefit.

Why it matters

Potential benefit: If successful, this could provide an affordable, home-based way for people with knee replacements to increase daily activity and improve long-term health.

How similar studies have performed: Automated online physical-activity programs have shown benefits in other older-adult groups, but they have rarely been tested specifically after total knee replacement.

Where this research is happening

Columbia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
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Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.