Condition
Total Knee Arthroplasty (TKA) clinical trials and research
As of November 12, 2026, Find a Trial lists 6 Total Knee Arthroplasty (TKA) clinical trials that are recruiting, at sites in 3 countries (most in United States (3), Poland (2), China (1)). By phase: Phase 3 (2), Phase 4 (1), Phase 1/2 (1). The most active sponsors are Medical University of Warsaw (2), Hospital for Special Surgery, New York (2). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 6Clinical trials
- 3Countries
Newest Total Knee Arthroplasty (TKA) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Suzetrigine for pain relief after knee replacement | Phase 3 | New York, New York | Recruiting | Oct 8, 2026 |
| Suzetrigine for pain relief after knee replacement | Phase 3 | New York, New York | Recruiting | Oct 8, 2026 |
| Total IV anesthesia vs spinal anesthesia for same-day discharge after knee replacement | Phase 1/2 | Chicago, Illinois | Recruiting | Jun 26, 2026 |
| Imageless vs. image-based navigation in robot-assisted knee replacement | — | Warsaw, Mazovian | Recruiting | Apr 13, 2026 |
| Rare metals and immune markers in hip and knee tissue from patients having joint replacement | — | Ostrów Mazowiecka, Masovian Voivodeship | Recruiting | Jan 16, 2026 |
| Timing nalbuphine for pain relief and blood pressure control during knee replacement in older adults | Phase 4 | Jinan, Shandong | Recruiting | Dec 9, 2025 |
All recruiting trials (6)
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Suzetrigine for pain relief after knee replacement
This trial tests whether suzetrigine can reduce opioid use after a total knee replacement compared with placebo.
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Suzetrigine for pain relief after knee replacement
This trial tests whether suzetrigine can reduce opioid use after a total knee replacement compared with placebo.
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Total IV anesthesia vs spinal anesthesia for same-day discharge after knee replacement
This study tests whether using total intravenous anesthesia (TIVA) or spinal anesthesia helps adults have same-day discharge after a primary total knee replacement.
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Imageless vs. image-based navigation in robot-assisted knee replacement
This study tests whether imageless navigation is as good as image-based navigation for robotic-assisted total knee replacement in people with knee osteoarthritis.
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Rare metals and immune markers in hip and knee tissue from patients having joint replacement
This project will see if levels of rare metals, trace elements, and certain immune markers are low in the joint tissue and blood of adults having hip or knee replacement for osteoarthritis.
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Timing nalbuphine for pain relief and blood pressure control during knee replacement in older adults
We will test whether giving nalbuphine at different times during knee replacement helps control pain and stabilize blood pressure in people 65 and older.
Related topics
Quick answers
How many Total Knee Arthroplasty (TKA) clinical trials are recruiting right now?
6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (3 trials), Poland (2 trials), China (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 2, Phase 4: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.