Improving function and reducing pain after knee replacement through physical activity and weight loss
Official title: Physical Activity and Weight Loss to Improve Function and Pain after Total Knee Replacement
Funded at University of South Carolina at Columbia · NIH-10884200 · Data updated 2026-11-12
This study is looking at how a personalized weight loss program can help people recover better and feel healthier after knee replacement surgery, and it’s for those who want to improve their recovery and overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | July 15, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $581,896 |
| NIH project number | 5R01AG070004-04 |
| Project ID | NIH-10884200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are undergoing total knee replacement and may be overweight or inactive.
✕Less likely to help
Patients who are not undergoing total knee replacement or those who are not overweight may not benefit from this research.
What this research studies
This research investigates how a tailored weight loss program can enhance recovery and overall health for patients who have undergone total knee replacement (TKR). It involves a two-arm randomized controlled trial where participants will either engage in a patient-centered weight loss program or a control group focused on chronic disease self-management. The program aims to address the common issues of obesity and inactivity that many TKR patients face, which can lead to poor recovery outcomes. By starting the program 12 weeks post-surgery and continuing for a year, the study seeks to improve physical function and reduce the risk of complications.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery outcomes and quality of life for patients after knee replacement surgery.
How similar studies have gone: Previous research has shown that weight management and physical activity can significantly improve recovery outcomes in similar patient populations.
Where this research is happening
-
University of South Carolina at Columbia
Columbia, United States Active
Researchers
- Principal investigator: Pellegrini, Christine Ann — University of South Carolina at Columbia
- Study coordinator: Pellegrini, Christine Ann
Related research
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Improving Function and Pain After Total Knee Replacement Through Physical Activity and Weight Loss
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.