Remote-based physical activity program for adults after total knee replacement
Official title: Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement
Funded at University of South Carolina at Columbia · NIH-11392375 · Data updated 2026-11-12
A nationwide study tests a scalable, online program to help adults 12 months after knee replacement stay active and healthier without in-person visits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $607,918 |
| NIH project number | 5R01AG088083-03 |
| Project ID | NIH-11392375 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21+ who are at least 12 months post-total knee replacement and able to participate in a remote activity program.
✕Less likely to help
Individuals unable to use internet-based programs or who have contraindications to increased physical activity may not benefit.
What this research studies
This project adapts and tests an internet-based Energize! program to help adults who are at least a year post-total knee replacement increase daily physical activity. Using the Multiphase Optimization Strategy (MOST), researchers will identify which components of the intervention work best when delivered remotely. All participants get a core 6-month automated program with activity planning, video lessons, homework, and automated feedback, while randomization adds several optional components. The goal is to find a scalable approach that improves activity levels while reducing barriers like time and travel.
Why it matters
Potential benefit: If successful, patients could enjoy a more active lifestyle after knee replacement through a low-burden, online program.
How similar studies have gone: Past thi s line of online activity programs show promise, but this study tests scalability and optimization in post-TKR patients.
Where this research is happening
-
University of South Carolina at Columbia
Columbia, United States Active
Researchers
- Principal investigator: Pellegrini, Christine Ann — University of South Carolina at Columbia
- Study coordinator: Pellegrini, Christine Ann
Related research
Other NIH-funded projects on the same topics.
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Self-powered knee implant load sensors to monitor total knee replacements
A tiny, self-powered sensor system is being developed to monitor the loads on a total knee replacement so doctors can keep an eye on implant health from afar.
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Self-powered knee implant that measures how your knee moves and bears weight inside the body
A new knee replacement implant will quietly power and transmit measurements of your knee’s movement and the forces across the joint during daily life.
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How neighborhood and social factors influence when people get knee replacement
This project looks at how neighborhood, healthcare access, and social circumstances affect when adults who need knee replacement actually receive surgery.
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Remote exercise program for people with knee replacements
Different online program features will be tried to help adults who had a total knee replacement become more active.
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Investigating how social factors affect the timing of total knee replacement surgery
This study looks at when people in the U.S. get knee replacement surgeries and how things like access to healthcare and living conditions affect that timing, so we can find ways to help more patients get the care they need when they need it.
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Improving Function and Pain After Total Knee Replacement Through Physical Activity and Weight Loss
This program helps adults who have had total knee replacement surgery improve their movement and reduce pain by focusing on physical activity and healthy weight.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.