NIH-funded research R01 grant

Remote-based physical activity program for adults after total knee replacement

Official title: Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement

Funded at University of South Carolina at Columbia · NIH-11392375 · Data updated 2026-11-12

A nationwide study tests a scalable, online program to help adults 12 months after knee replacement stay active and healthier without in-person visits.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of South Carolina at Columbia
NIH-funded
Lab location1 site (Columbia, United States)
Project startAugust 15, 2024
Project endJuly 31, 2029
Funding year2026
Award (this year)$607,918
NIH project number5R01AG088083-03
Project IDNIH-11392375 on NIH RePORTER

Who could benefit from this research

Could help

Adults aged 21+ who are at least 12 months post-total knee replacement and able to participate in a remote activity program.

Less likely to help

Individuals unable to use internet-based programs or who have contraindications to increased physical activity may not benefit.

What this research studies

This project adapts and tests an internet-based Energize! program to help adults who are at least a year post-total knee replacement increase daily physical activity. Using the Multiphase Optimization Strategy (MOST), researchers will identify which components of the intervention work best when delivered remotely. All participants get a core 6-month automated program with activity planning, video lessons, homework, and automated feedback, while randomization adds several optional components. The goal is to find a scalable approach that improves activity levels while reducing barriers like time and travel.

Why it matters

Potential benefit: If successful, patients could enjoy a more active lifestyle after knee replacement through a low-burden, online program.

How similar studies have gone: Past thi s line of online activity programs show promise, but this study tests scalability and optimization in post-TKR patients.

Where this research is happening

  • University of South Carolina at Columbia
    Columbia, United States
    Active

Researchers

  • Principal investigator: Pellegrini, Christine Ann — University of South Carolina at Columbia
  • Study coordinator: Pellegrini, Christine Ann

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.