Understanding how tobacco smoking affects the brain in people with HIV
Official title: Neurometabolic profile of tobacco smoking in HIV-infected Individuals
Funded at Children's Hosp of Philadelphia · NIH-10894835 · Data updated 2026-11-12
This study is looking at how smoking and HIV affect the brain's chemistry, using a special imaging technique to see changes in the brain, and it aims to help people with HIV who smoke by finding better ways to get clear images of their brains.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00DA051315-04 |
| Project ID | NIH-10894835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are HIV-infected individuals who are also tobacco smokers.
✕Less likely to help
Patients who do not smoke or are not infected with HIV may not benefit from this research.
What this research studies
This research investigates the combined effects of tobacco smoking and HIV infection on brain chemistry. It utilizes a novel imaging technique called HERCULES to measure brain metabolites that may be altered by these conditions. The study aims to develop methods to correct for motion during imaging, which is particularly important for individuals who may experience impulsivity. By understanding these neurochemical changes, the research seeks to improve health outcomes for HIV-infected individuals who smoke.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for HIV-infected individuals who smoke, potentially improving their cognitive function and overall health.
How similar studies have gone: Previous research has shown that understanding the neurochemical impacts of smoking in various populations can lead to significant health improvements, suggesting this approach has potential for success.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Saleh, Muhammad G — Children's Hosp of Philadelphia
- Study coordinator: Saleh, Muhammad G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.