Condition

SCLC clinical trials and research

• 14Clinical trials
• 30NIH research projects
• 20Countries

Newest SCLC clinical trials

All recruiting trials (14)

• BL-M14D1 plus atezolizumab vs standard therapy in first-line extensive-stage small cell lung cancer

  A first-line treatment for adults with extensive-stage small cell lung cancer tests whether adding BL-M14D1 to atezolizumab and standard chemotherapy helps more than standard care.

  Recruiting at 7 sites Phase 3 SystImmune Inc. · Springdale, Arkansas and 61 other locations · NCT07625644

• Using a new PFD3 PET tracer to find and stage small cell lung cancer

  This test will try a new PET tracer called PFD3 in adults with small cell lung cancer to see if it detects tumors and stages disease more accurately than standard FDG PET/CT.

  Recruiting Phase 1/2 Peking University First Hospital · Beijing, Beijing Municipality · NCT07508852

• HLX3901 for advanced small cell lung cancer or neuroendocrine carcinoma

  This study will test whether IV HLX3901 is safe and how the body processes it in adults with advanced small cell lung cancer or neuroendocrine carcinoma who have progressed after platinum-based therapy.

  Recruiting Phase 1 Shanghai Henlius Biotech · Beijing and 1 other locations · NCT07416695

• Golidocitinib plus PD-1 inhibitor maintenance for previously untreated extensive-stage small cell lung cancer

  This trial will see if adding golidocitinib to PD-1 inhibitor maintenance helps people with previously untreated extensive-stage small cell lung cancer.

  Recruiting at 2 sites Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing and 1 other locations · NCT07110103

• Cognitive screening for lung cancer patients

  This study is trying to see if lung cancer and its treatments affect thinking skills in patients during their first year after diagnosis.

  Recruiting European Institute of Oncology · Milan · NCT06727370

• Testing TUB-030 for advanced solid tumors

  This study is testing a new drug called TUB-030 to see if it can safely help adults with advanced solid tumors, especially those with head and neck cancer or non-small cell lung cancer.

  Recruiting at 19 sites Phase 1/2 Gilead Sciences · New Haven, Connecticut and 19 other locations · NCT06657222

• Milaberon for treating advanced solid tumors

  This study is testing if a higher dose of mirabegron can help people with advanced solid tumors feel better while keeping an eye on any side effects.

  Recruiting Phase 2 Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06534762

• Combining Adebrelimab and Apatinib for Small Cell Lung Cancer Maintenance

  This study is testing if a combination of two drugs, Adebrelimab and Apatinib, can help people with extensive-stage small cell lung cancer stay healthy after their initial chemotherapy.

  Recruiting Phase 2 Tang-Du Hospital · Xi'an, Shannxi · NCT06475209

• Evaluating ZL-1310 for Small Cell Lung Cancer

  This study is testing a new drug called ZL-1310, alone and with other treatments, to see if it can help people with advanced small cell lung cancer who haven't responded to previous chemotherapy.

  Recruiting at 32 sites Phase 1 Zai Lab (Hong Kong), Ltd. · Duarte, California and 40 other locations · NCT06179069

• Adaptive radiotherapy using a new linear accelerator for cancer treatment

  This study is testing a new way to adjust radiation therapy for cancer patients each day based on changes in their tumors to see if it improves treatment.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT06116019

• Evaluating the safety and effectiveness of Zepzelca™ injection for small cell lung cancer

  This study is testing if the Zepzelca™ injection is safe and effective for people with small cell lung cancer that hasn't improved after their first treatment.

  Recruiting Boryung Pharmaceutical Co., Ltd · Seoul · NCT06021483

• Combination treatment for extensive stage small cell lung cancer

  This study is testing a new combination treatment for people with extensive stage small cell lung cancer to see if it helps them live longer and feel better.

  Recruiting at 4 sites Phase 2 Hoosier Cancer Research Network · Indianapolis, Indiana and 3 other locations · NCT05903092

• First-in-human use of JAB-8263 in adults with advanced solid and blood cancers

  This trial will try JAB-8263, a BET inhibitor pill, in adults with advanced solid tumors or blood cancers that have progressed after standard treatments.

  Recruiting Phase 1/2 Jacobio Pharmaceuticals Co., Ltd. · Tianjin, Tianjin Municipality · NCT04686682

• Evaluating PC14586 for advanced solid tumors with a specific mutation

  This study is testing a new oral medication called PC14586 to see if it can help people with advanced solid tumors that have a specific mutation in the TP53 gene.

  Recruiting at 71 sites Phase 1/2 PMV Pharmaceuticals, Inc · Irvine, California and 75 other locations · NCT04585750

NIH-funded research (30)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Role of Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC in the Immunotherapy Era

  This project looks at whether giving twice-daily radiotherapy for limited-stage small cell lung cancer still helps patients today who are also getting immunotherapy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11464739

• SCLC model creation and therapy testing

  A cancer research program using mouse models and engineered human and mouse cells to study small cell lung cancer and test potential treatments.

  NIH research New York University School of Medicine · New York, United States · NIH-11390990

• Impact of genetic changes on SCLC subtypes and treatment response

  This project explores how specific genetic changes in small cell lung cancer (SCLC) affect the disease and how it responds to targeted drugs.

  NIH research New York University School of Medicine · New York, United States · NIH-11390989

• Repair mechanisms for DNA lesions in small cell lung cancer

  Researchers are studying how cancer cells with small cell lung cancer respond or become resistant to treatment by looking at the ways DNA damage is repaired.

  NIH research New York University School of Medicine · New York, United States · NIH-11390987

• Understanding how replication stress affects a hard-to-treat breast cancer gene patients may carry

  This grant explores how certain breast cancer gene defects interact with replication stress to influence cancer cell survival and treatment resistance, with potential implications for therapies in patients with BRCA2-related breast cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-11390986

• Replication Stress Sensing Defects in Small Cell Lung Cancer

  A study in people might not be involved directly, but it aims to understand why a common lung cancer responds poorly to therapy over time by examining how cancer cells handle replication stress.

  NIH research New York University School of Medicine · New York, United States · NIH-11390984

• Targeting DHX9 to boost viral-like immune response in Small Cell Lung Cancer

  A scientist team is testing whether blocking a protein called DHX9 can make aggressive small cell lung cancer more visible to the immune system and more responsive to immunotherapy.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11386506

• Platinum-related lipid changes and immune environment in small cell lung cancer

  A patient-friendly look at how platinum chemotherapy may alter fats in tumor cells and the immune system in small cell lung cancer to inform better treatments.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11365857

• How NEUROD1 shapes small cell lung cancer behavior

  This project looks at how the protein NEUROD1 changes small cell lung cancer cells and whether that points to new treatment options for people with SCLC.

  NIH research Duke University · Durham, United States · NIH-11294337

• Treating small cell lung cancer that stops responding to therapy

  This project tests new ways to make small cell lung cancer that has become resistant to chemotherapy, radiation, or immunotherapy more responsive to treatment.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11286788

• Why some small cell lung cancers stop responding to cisplatin

  This project looks at how a specific NFIB–MAST1 signaling pathway may cause cisplatin resistance in small cell lung cancer (SCLC), aiming to help people whose cancer returns after initial chemotherapy.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11283999

• Small cell lung cancer interactions with liver blood-vessel cells

  This work looks at whether contact between small cell lung cancer cells and liver blood-vessel cells changes both cell types and points to new treatment targets for people whose cancer has spread to the liver.

  NIH research Washington University · Saint Louis, United States · NIH-11257728

• New models of small cell lung cancer to test treatments

  Scientists are building new mouse and human cell models of small cell lung cancer to test drug combinations that might work better for patients with this cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-11171416

• Targeting weak spots in small cell lung cancer subtypes to improve treatment

  Researchers are trying CDK2 and PARP drugs, alone and with immunotherapy, for people who have different genetic subtypes of small cell lung cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-11171407

• How small cell lung cancer fixes DNA damage during treatment

  Researchers are looking at how small cell lung cancer cells get and repair DNA damage during therapy to understand why some tumors respond and others become resistant.

  NIH research New York University School of Medicine · New York, United States · NIH-11171396

• Why small cell lung cancer survives DNA replication stress

  This project looks for the molecular tricks small cell lung cancer (SCLC) uses to tolerate DNA damage so new treatments can help people whose tumors resist chemotherapy.

  NIH research New York University School of Medicine · New York, United States · NIH-11171388

• How small cell lung cancer becomes resistant to chemotherapy

  The team is looking at how changes in a gene called SLFN11 affect whether small cell lung cancer responds to chemotherapy.

  NIH research New York University School of Medicine · New York, United States · NIH-11171382

• Understanding Small Cell Lung Cancer to Discover New Treatments

  This research aims to understand how small cell lung cancer develops and resists treatment, hoping to find new ways to fight this aggressive disease.

  NIH research Stanford University · Stanford, United States · NIH-11159419

• Blocking DHX9 to wake the immune system against small cell lung cancer

  The team will block a protein called DHX9 in small cell lung cancer to trigger virus-like signals in tumors so they may respond better to immunotherapy.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11158849

• Understanding how platinum chemotherapy affects the immune system in small cell lung cancer

  This research explores why current immune therapies for small cell lung cancer might not work as well as hoped, focusing on how chemotherapy affects the body's immune cells.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11115843

• Understanding the differences in small cell lung cancer and how they affect treatment outcomes

  This study is looking at the different ways small cell lung cancer can behave in order to find out how these differences affect treatment and chances of coming back, so that doctors can create better, personalized treatment plans just for you.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11092311

• Understanding how NEUROD1 affects small cell lung cancer behavior

  This study is looking at how a gene called NEUROD1 affects small cell lung cancer, with the goal of finding new ways to treat this tough type of cancer and help patients feel better.

  NIH research Duke University · Durham, United States · NIH-11053607

• Finding new ways to treat small cell lung cancer

  This study is looking at ways to improve treatments for small cell lung cancer by understanding why some therapies don't work and how we can boost the immune system to fight the cancer better, and patients may have the chance to try new treatment combinations in the process.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11032866

• Understanding how cancer cells interact with blood vessel cells in liver metastasis of small cell lung cancer.

  This study is looking at how small cell lung cancer cells interact with the cells that line blood vessels, especially when the cancer spreads to the liver, to find out how these interactions might affect cancer growth and make treatments less effective, with the hope of discovering new ways to fight the disease.

  NIH research Washington University · Saint Louis, United States · NIH-11012340

• Using a new approach to enhance immune response in Small Cell Lung Cancer

  This study is exploring a new way to boost immunotherapy for people with Small Cell Lung Cancer by targeting a protein called DHX9, which could help turn less responsive tumors into ones that the immune system can better fight.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-10981356

• Understanding how small cell lung cancer develops to find new treatments

  This study is looking into how small cell lung cancer develops and changes, with the goal of finding better treatments to help patients feel better and live longer.

  NIH research Stanford University · Stanford, United States · NIH-10911215

• Understanding and overcoming resistance to cancer treatments in small cell lung cancer

  This study is looking at why small cell lung cancer sometimes stops responding to chemotherapy, using special models that mimic the disease, to find new ways to help patients who face a relapse.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10900664

• Investigating how NFIB-MAST1 signaling affects resistance to cisplatin in small cell lung cancer.

  This study is looking at how small cell lung cancer cells become resistant to cisplatin, a common chemotherapy drug, to help find better treatment options for patients like you.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-10880050

• Investigating how platinum chemotherapy affects immune responses in small cell lung cancer

  This study is looking at how a common chemotherapy treatment affects the immune system in patients with small cell lung cancer, with the goal of finding better ways to help the body fight the cancer using immune therapies.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-10868735

• Detecting early signs of small cell lung cancer using specific antibodies

  This study is looking for new ways to spot small cell lung cancer early by checking for specific antibodies in the blood, which could help doctors diagnose the disease sooner and improve survival rates for patients.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10732773

Related topics

Quick answers

How many SCLC clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in China (7 trials), United States (5 trials), Spain (4 trials), Germany (3 trials), Italy (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 4, Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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