Adaptive radiotherapy using a new linear accelerator for cancer treatment
Official title: A Prospective Study on Online Adaptive Radiotherapy (ART) Using the ETHOS Linear Accelerator for Various Tumor Entities and the Feasibility of Integrating Multi-Parametric Patient Data Into the Adaptive Workflow
Run by Charite University, Berlin, Germany · NCT06116019 · Data updated 2026-11-12
This study is testing a new way to adjust radiation therapy for cancer patients each day based on changes in their tumors to see if it improves treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 649 (estimated) |
| Sponsor | Charite University, Berlin, Germany Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Berlin) |
| Status | Recruiting |
| Started | October 11, 2023 |
| Main results expected | October 9, 2026 |
| Study ends | October 9, 2027 |
| Registry record updated | November 3, 2023 |
| Trial ID | NCT06116019 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adult patients over 18 years old with any tumor type requiring radiotherapy or chemoradiotherapy.
✕Probably not a fit
Patients who are pregnant or unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the use of the Varian/SHS ETHOS treatment system for online adaptive radiotherapy (ART) in patients with various types of cancer. It aims to dynamically adjust radiation treatment plans on a daily basis to accommodate changes in tumor size or position, utilizing cone beam computed tomography for real-time imaging. The study will assess the feasibility and acceptability of ART across different tumor types and integrate patient-reported outcomes to enhance treatment monitoring. This is an observational study that will gather data over several weeks of therapy.
Why it matters
Potential benefit: If successful, this approach could lead to more precise and effective radiation therapy, improving treatment outcomes for cancer patients.
How similar studies have gone: While the concept of adaptive radiotherapy is established, the specific application of the ETHOS system represents a novel approach that has not been widely tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (\>18 years) * All tumor entities with an indication for radiotherapy and/or chemoradiotherapy * Signed informed consent Exclusion Criteria: * Pregnancy * Patients who are not capable of giving consent
Where it's running
-
Charité - Universitätsmedizin
Berlin, Germany Recruiting
Study contacts
- Study coordinator: Goda Kalinauskaite, MD
- Email: goda.kalinauskaite@charite.de
- Phone: +49 30 450 527318
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Testing trastuzumab deruxtecan (T‑DxD) for HER2‑positive advanced solid tumors
This will test whether trastuzumab deruxtecan (T‑DxD) helps adults in the US with HER2‑positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have had prior systemic treatment and have no satisfactory alternative options.
-
Investigating HER3-DXd for advanced solid tumors
This study is testing a new drug called HER3-DXd to see if it can safely help people with advanced solid tumors like melanoma, head and neck cancer, and gastric cancer who have already tried other treatments.
-
Validation of a blood test for early cancer detection and monitoring
This study is testing a blood test to see if it can help find different types of cancer early and monitor patients after treatment.
-
Evaluating PC14586 for advanced solid tumors with a specific mutation
This study is testing a new oral medication called PC14586 to see if it can help people with advanced solid tumors that have a specific mutation in the TP53 gene.
-
Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes
This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.
-
Evaluating progastrin levels in cancer patients
This study is testing if measuring progastrin levels in the blood can help predict how cancer will progress and respond to treatment in patients with different types of cancer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.