Clinical trial Recruiting at 1 site Observational Ages 18 and up

Adaptive radiotherapy using a new linear accelerator for cancer treatment

Official title: A Prospective Study on Online Adaptive Radiotherapy (ART) Using the ETHOS Linear Accelerator for Various Tumor Entities and the Feasibility of Integrating Multi-Parametric Patient Data Into the Adaptive Workflow

Run by Charite University, Berlin, Germany · NCT06116019 · Data updated 2026-11-12

This study is testing a new way to adjust radiation therapy for cancer patients each day based on changes in their tumors to see if it improves treatment.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment649 (estimated)
SponsorCharite University, Berlin, Germany
Academic / other
Drugs / interventionsradiation
Locations1 site (Berlin)
StatusRecruiting
StartedOctober 11, 2023
Main results expectedOctober 9, 2026
Study endsOctober 9, 2027
Registry record updatedNovember 3, 2023
Trial IDNCT06116019 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adult patients over 18 years old with any tumor type requiring radiotherapy or chemoradiotherapy.

Probably not a fit

Patients who are pregnant or unable to provide informed consent will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the use of the Varian/SHS ETHOS treatment system for online adaptive radiotherapy (ART) in patients with various types of cancer. It aims to dynamically adjust radiation treatment plans on a daily basis to accommodate changes in tumor size or position, utilizing cone beam computed tomography for real-time imaging. The study will assess the feasibility and acceptability of ART across different tumor types and integrate patient-reported outcomes to enhance treatment monitoring. This is an observational study that will gather data over several weeks of therapy.

Why it matters

Potential benefit: If successful, this approach could lead to more precise and effective radiation therapy, improving treatment outcomes for cancer patients.

How similar studies have gone: While the concept of adaptive radiotherapy is established, the specific application of the ETHOS system represents a novel approach that has not been widely tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult patients (\>18 years)
* All tumor entities with an indication for radiotherapy and/or chemoradiotherapy
* Signed informed consent

Exclusion Criteria:

* Pregnancy
* Patients who are not capable of giving consent

Where it's running

  • Charité - Universitätsmedizin
    Berlin, Germany
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.