Understanding how NEUROD1 affects small cell lung cancer behavior
Official title: NEUROD1 function in SCLC fate and plasticity
Funded at Duke University · NIH-11053607 · Data updated 2026-11-12
This study is looking at how a gene called NEUROD1 affects small cell lung cancer, with the goal of finding new ways to treat this tough type of cancer and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $535,073 |
| NIH project number | 5R01CA262134-02 |
| Project ID | NIH-11053607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with small cell lung cancer, particularly those whose tumors exhibit NEUROD1 expression.
✕Less likely to help
Patients with non-small cell lung cancer or those whose tumors do not express NEUROD1 may not benefit from this research.
What this research studies
This research investigates the role of NEUROD1 in small cell lung cancer (SCLC), a highly aggressive form of lung cancer. The study aims to identify how NEUROD1 influences the cancer's development and response to treatment, particularly focusing on the molecular subtypes of SCLC. By analyzing the genetic and molecular characteristics of these subtypes, the research seeks to uncover new therapeutic targets that could lead to more effective treatments for patients. The approach includes examining the interactions between various oncogenic transcription factors and their impact on cancer cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that significantly improve survival rates for patients with small cell lung cancer.
How similar studies have gone: Previous research has shown promising results in targeting specific molecular subtypes of cancer, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Oliver, Trudy Gale — Duke University
- Study coordinator: Oliver, Trudy Gale
Related research
Other NIH-funded projects on the same topics.
-
Role of Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC in the Immunotherapy Era
This project looks at whether giving twice-daily radiotherapy for limited-stage small cell lung cancer still helps patients today who are also getting immunotherapy.
-
SCLC model creation and therapy testing
A cancer research program using mouse models and engineered human and mouse cells to study small cell lung cancer and test potential treatments.
-
Impact of genetic changes on SCLC subtypes and treatment response
This project explores how specific genetic changes in small cell lung cancer (SCLC) affect the disease and how it responds to targeted drugs.
-
Repair mechanisms for DNA lesions in small cell lung cancer
Researchers are studying how cancer cells with small cell lung cancer respond or become resistant to treatment by looking at the ways DNA damage is repaired.
-
Understanding how replication stress affects a hard-to-treat breast cancer gene patients may carry
This grant explores how certain breast cancer gene defects interact with replication stress to influence cancer cell survival and treatment resistance, with potential implications for therapies in patients with BRCA2-related breast cancer.
-
Replication Stress Sensing Defects in Small Cell Lung Cancer
A study in people might not be involved directly, but it aims to understand why a common lung cancer responds poorly to therapy over time by examining how cancer cells handle replication stress.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.