Understanding how NEUROD1 affects small cell lung cancer behavior
NEUROD1 function in SCLC fate and plasticity
This study is looking at how a gene called NEUROD1 affects small cell lung cancer, with the goal of finding new ways to treat this tough type of cancer and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11053607 on NIH RePORTER |
What this research studies
This research investigates the role of NEUROD1 in small cell lung cancer (SCLC), a highly aggressive form of lung cancer. The study aims to identify how NEUROD1 influences the cancer's development and response to treatment, particularly focusing on the molecular subtypes of SCLC. By analyzing the genetic and molecular characteristics of these subtypes, the research seeks to uncover new therapeutic targets that could lead to more effective treatments for patients. The approach includes examining the interactions between various oncogenic transcription factors and their impact on cancer cell behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with small cell lung cancer, particularly those whose tumors exhibit NEUROD1 expression.
Not a fit: Patients with non-small cell lung cancer or those whose tumors do not express NEUROD1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that significantly improve survival rates for patients with small cell lung cancer.
How similar studies have performed: Previous research has shown promising results in targeting specific molecular subtypes of cancer, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Oliver, Trudy Gale — Duke University
- Study coordinator: Oliver, Trudy Gale
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.