Platinum-related lipid changes and immune environment in small cell lung cancer
Official title: Platinum-induced lipid reprogramming and tumor immune microenvironment in SCLC
Funded at University of Texas Hlth Science Center · NIH-11365857 · Data updated 2026-11-12
A patient-friendly look at how platinum chemotherapy may alter fats in tumor cells and the immune system in small cell lung cancer to inform better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $351,245 |
| NIH project number | 5R01CA269782-05 |
| Project ID | NIH-11365857 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with small cell lung cancer who are undergoing or eligible for platinum-based chemotherapy and/or immunotherapy may contribute samples or participate in related studies.
✕Less likely to help
Patients whose tumors do not show the examined lipid-immune interactions may not directly benefit from this specific research.
What this research studies
This project explores how platinum-based chemotherapy might change lipid content in tumor cells and how that affects immune cells in the tumor, possibly helping or hindering immune therapy. Researchers study dendritic cells and tumor-derived exosomes to understand why some patients respond poorly to immune checkpoint inhibitors. The work uses human cancer samples and laboratory models to map the interactions between lipids, tumor cells, and the immune system. The goal is to identify mechanisms that could guide more effective therapies for small cell lung cancer.
Why it matters
Potential benefit: Understanding these mechanisms could lead to more effective combinations of chemotherapy and immunotherapy for small cell lung cancer.
How similar studies have gone: Previous studies have linked tumor lipids and immune dysfunction to therapy resistance, suggesting potential but not guaranteed benefit for new strategies.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Jin, Lingtao — University of Texas Hlth Science Center
- Study coordinator: Jin, Lingtao
Related research
Other NIH-funded projects on the same topics.
-
Role of Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC in the Immunotherapy Era
This project looks at whether giving twice-daily radiotherapy for limited-stage small cell lung cancer still helps patients today who are also getting immunotherapy.
-
SCLC model creation and therapy testing
A cancer research program using mouse models and engineered human and mouse cells to study small cell lung cancer and test potential treatments.
-
Impact of genetic changes on SCLC subtypes and treatment response
This project explores how specific genetic changes in small cell lung cancer (SCLC) affect the disease and how it responds to targeted drugs.
-
Repair mechanisms for DNA lesions in small cell lung cancer
Researchers are studying how cancer cells with small cell lung cancer respond or become resistant to treatment by looking at the ways DNA damage is repaired.
-
Understanding how replication stress affects a hard-to-treat breast cancer gene patients may carry
This grant explores how certain breast cancer gene defects interact with replication stress to influence cancer cell survival and treatment resistance, with potential implications for therapies in patients with BRCA2-related breast cancer.
-
Replication Stress Sensing Defects in Small Cell Lung Cancer
A study in people might not be involved directly, but it aims to understand why a common lung cancer responds poorly to therapy over time by examining how cancer cells handle replication stress.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.