Understanding and overcoming resistance to cancer treatments in small cell lung cancer
Dissecting and overcoming cross-resistance to DNA damaging agents in SCLC
This study is looking at why small cell lung cancer sometimes stops responding to chemotherapy, using special models that mimic the disease, to find new ways to help patients who face a relapse.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10900664 on NIH RePORTER |
What this research studies
This research focuses on small cell lung cancer (SCLC), a highly aggressive form of cancer that often becomes resistant to chemotherapy after initial treatment. The team is investigating the molecular mechanisms behind this resistance using patient-derived models that mimic the disease's progression. By analyzing these models, they aim to identify potential biomarkers and therapeutic targets that could lead to more effective treatments for patients who experience relapse. The research utilizes advanced techniques to study how cancer cells respond to various DNA damaging agents.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with small cell lung cancer who have undergone initial chemotherapy and are experiencing relapse.
Not a fit: Patients with small cell lung cancer who have not received prior chemotherapy or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with relapsed small cell lung cancer.
How similar studies have performed: Previous research has shown promise in understanding cancer resistance mechanisms, but this approach using patient-derived models is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Drapkin, Benjamin J — Ut Southwestern Medical Center
- Study coordinator: Drapkin, Benjamin J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.