Understanding how replication stress affects a hard-to-treat breast cancer gene patients may carry
Official title: Mechanisms of Replication Stress Tolerance in SCLC
Funded at New York University School of Medicine · NIH-11390986 · Data updated 2026-11-12
This grant explores how certain breast cancer gene defects interact with replication stress to influence cancer cell survival and treatment resistance, with potential implications for therapies in patients with BRCA2-related breast cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 16, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $351,711 |
| NIH project number | 5P01CA288368-03 |
| Project ID | NIH-11390986 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with BRCA2-related breast cancer or similar homologous recombination–deficient cancers could benefit from future targeted therapies arising from this research.
✕Less likely to help
Patients whose tumors do not involve replication stress vulnerabilities or BRCA2-related defects may not benefit.
What this research studies
Researchers at NYU Langone will study how cancer cells deal with replication stress, focusing on how these stress responses help tumor cells survive and resist chemotherapy. They will map the signaling pathways that combat replication stress in cancer cells and test how altering these pathways changes response to treatment in laboratory models. The goal is to identify vulnerable points that could be targeted to improve therapies for patients whose cancers carry BRCA2 and related gene mutations and are prone to relapse.
Why it matters
Potential benefit: If successful, the work could reveal new targets to overcome chemotherapy resistance in BRCA2-related breast cancers.
How similar studies have gone: Previous studies have shown replication stress pathways as promising targets; this project builds on those findings in a specific breast cancer context.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Huang, Tony Tung — New York University School of Medicine
- Study coordinator: Huang, Tony Tung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.