New models of small cell lung cancer to test treatments
Official title: SCLC Model Generation and Therapeutic Analysis
Funded at New York University School of Medicine · NIH-11171416 · Data updated 2026-11-12
Scientists are building new mouse and human cell models of small cell lung cancer to test drug combinations that might work better for patients with this cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 16, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $209,804 |
| NIH project number | 5P01CA288368-02 |
| Project ID | NIH-11171416 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with a diagnosis of small cell lung cancer, especially those who might enroll in future clinical trials or donate tumor samples, are the most relevant candidates.
✕Less likely to help
Patients without small cell lung cancer or whose tumors lack the specific genetic changes studied here are unlikely to benefit directly from this project.
What this research studies
From a patient's point of view, researchers will use gene-editing (CRISPR) to create human cell lines and genetically engineered mice that carry the same key mutations found in small cell lung cancer. They will share these standardized cell and animal models across the project so multiple teams can run the same treatment experiments. The team will use imaging and laboratory tests to track how tumors respond and measure drug effects in the models. Results will be used to compare single agents and combinations to guide which approaches move toward clinical testing.
Why it matters
Potential benefit: If successful, this work could help identify more effective drug combinations and speed the development of treatments for small cell lung cancer.
How similar studies have gone: Preclinical mouse and cell-line models have previously guided lung cancer drug development, but not all promising preclinical findings translate into patient benefit.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Poirier, John Thomas — New York University School of Medicine
- Study coordinator: Poirier, John Thomas
Related research
Other NIH-funded projects on the same topics.
-
Role of Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC in the Immunotherapy Era
This project looks at whether giving twice-daily radiotherapy for limited-stage small cell lung cancer still helps patients today who are also getting immunotherapy.
-
SCLC model creation and therapy testing
A cancer research program using mouse models and engineered human and mouse cells to study small cell lung cancer and test potential treatments.
-
Impact of genetic changes on SCLC subtypes and treatment response
This project explores how specific genetic changes in small cell lung cancer (SCLC) affect the disease and how it responds to targeted drugs.
-
Repair mechanisms for DNA lesions in small cell lung cancer
Researchers are studying how cancer cells with small cell lung cancer respond or become resistant to treatment by looking at the ways DNA damage is repaired.
-
Understanding how replication stress affects a hard-to-treat breast cancer gene patients may carry
This grant explores how certain breast cancer gene defects interact with replication stress to influence cancer cell survival and treatment resistance, with potential implications for therapies in patients with BRCA2-related breast cancer.
-
Replication Stress Sensing Defects in Small Cell Lung Cancer
A study in people might not be involved directly, but it aims to understand why a common lung cancer responds poorly to therapy over time by examining how cancer cells handle replication stress.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.