Understanding how small cell lung cancer develops to find new treatments
Official title: Investigating molecular and cellular mechanisms of SCLC development to identify novel therapeutic strategies
Funded at Stanford University · NIH-10911215 · Data updated 2026-11-12
This study is looking into how small cell lung cancer develops and changes, with the goal of finding better treatments to help patients feel better and live longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 9, 2019 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $913,132 |
| NIH project number | 5R35CA231997-06 |
| Project ID | NIH-10911215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with small cell lung cancer, particularly those with Rb mutations.
✕Less likely to help
Patients with other types of lung cancer or those without small cell lung cancer may not benefit from this research.
What this research studies
This research investigates the molecular and cellular mechanisms that lead to the development of small cell lung cancer (SCLC), a highly aggressive form of lung cancer. The team utilizes innovative techniques to study how cancer cells evolve and respond to treatments, focusing on the role of the retinoblastoma tumor suppressor gene. By examining these processes in detail, the researchers aim to uncover new therapeutic strategies that could improve patient outcomes. The study involves collaboration with various experts and employs advanced models to better understand SCLC biology.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies that significantly improve survival rates for patients with small cell lung cancer.
How similar studies have gone: Previous research has shown promising results in understanding cancer mechanisms, but this approach to SCLC is relatively novel and untested.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Sage, Julien — Stanford University
- Study coordinator: Sage, Julien
Related research
Other NIH-funded projects on the same topics.
-
Role of Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC in the Immunotherapy Era
This project looks at whether giving twice-daily radiotherapy for limited-stage small cell lung cancer still helps patients today who are also getting immunotherapy.
-
SCLC model creation and therapy testing
A cancer research program using mouse models and engineered human and mouse cells to study small cell lung cancer and test potential treatments.
-
Impact of genetic changes on SCLC subtypes and treatment response
This project explores how specific genetic changes in small cell lung cancer (SCLC) affect the disease and how it responds to targeted drugs.
-
Repair mechanisms for DNA lesions in small cell lung cancer
Researchers are studying how cancer cells with small cell lung cancer respond or become resistant to treatment by looking at the ways DNA damage is repaired.
-
Understanding how replication stress affects a hard-to-treat breast cancer gene patients may carry
This grant explores how certain breast cancer gene defects interact with replication stress to influence cancer cell survival and treatment resistance, with potential implications for therapies in patients with BRCA2-related breast cancer.
-
Replication Stress Sensing Defects in Small Cell Lung Cancer
A study in people might not be involved directly, but it aims to understand why a common lung cancer responds poorly to therapy over time by examining how cancer cells handle replication stress.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.