SCLC model creation and therapy testing
Official title: SCLC Model Generation and Therapeutic Analysis
Funded at New York University School of Medicine · NIH-11390990 · Data updated 2026-11-12
A cancer research program using mouse models and engineered human and mouse cells to study small cell lung cancer and test potential treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 16, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $209,804 |
| NIH project number | 5P01CA288368-03 |
| Project ID | NIH-11390990 on NIH RePORTER |
Who could benefit from this research
✓Could help
This program targets preclinical models; patients may benefit in the long term from more accurate preclinical testing leading to better treatments.
✕Less likely to help
Patients directly enrolled are unlikely; the focus is on laboratory models and animal studies.
What this research studies
This grant focuses on making reliable cancer models by using CRISPR to edit genes in human and mouse cells and creating genetically engineered mouse models. Researchers will validate these models and share the cell lines for further study, then conduct in vivo therapy testing using imaging and pharmacodynamic analyses. The work aims to standardize how treatment studies are run across multiple projects to better understand which therapies might work for small cell lung cancer. The project leverages advanced animal models, genome editing, and in vivo evaluation to connect genetic changes with treatment responses.
Why it matters
Potential benefit: If successful, this work could streamline the discovery of effective therapies for small cell lung cancer and improve how preclinical drug testing predicts human responses.
How similar studies have gone: Previous work has shown that genetically engineered models can predict drug response and guide therapy development in cancer.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Poirier, John Thomas — New York University School of Medicine
- Study coordinator: Poirier, John Thomas
Related research
Other NIH-funded projects on the same topics.
-
Role of Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC in the Immunotherapy Era
This project looks at whether giving twice-daily radiotherapy for limited-stage small cell lung cancer still helps patients today who are also getting immunotherapy.
-
Impact of genetic changes on SCLC subtypes and treatment response
This project explores how specific genetic changes in small cell lung cancer (SCLC) affect the disease and how it responds to targeted drugs.
-
Repair mechanisms for DNA lesions in small cell lung cancer
Researchers are studying how cancer cells with small cell lung cancer respond or become resistant to treatment by looking at the ways DNA damage is repaired.
-
Understanding how replication stress affects a hard-to-treat breast cancer gene patients may carry
This grant explores how certain breast cancer gene defects interact with replication stress to influence cancer cell survival and treatment resistance, with potential implications for therapies in patients with BRCA2-related breast cancer.
-
Replication Stress Sensing Defects in Small Cell Lung Cancer
A study in people might not be involved directly, but it aims to understand why a common lung cancer responds poorly to therapy over time by examining how cancer cells handle replication stress.
-
Targeting DHX9 to boost viral-like immune response in Small Cell Lung Cancer
A scientist team is testing whether blocking a protein called DHX9 can make aggressive small cell lung cancer more visible to the immune system and more responsive to immunotherapy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.