Condition

Scar clinical trials and research

• 15Clinical trials
• 19NIH research projects
• 10Countries

Newest Scar clinical trials

All recruiting trials (15)

• Disposable noninvasive skin closure to help healing and reduce scarring after plastic surgery

  This study tests a disposable noninvasive skin closure device on one side of a plastic surgery incision to see if it helps wounds heal better and results in less scarring.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT07849010

• Phase II test of 9MW3811 for pathological scars

  This trial will try injections of 9MW3811 to see if they improve pathological scars in adults compared with placebo.

  Recruiting Phase 2 Mabwell (Shanghai) Bioscience Co., Ltd. · Shanghai, Shanghai Municipality · NCT07576608

• Myofascial release versus deep friction massage for C-section scar healing and abdominal recovery

  This study will test whether myofascial release or deep friction massage helps women with long-term C-section scar pain improve abdominal recovery and scar symptoms.

  Recruiting Cairo University · Alexandria · NCT07130747

• Effects of shock wave therapy on surgical scars

  This study is testing whether shock wave therapy can help improve the appearance and symptoms of surgical scars in patients who have had procedures like tummy tucks and breast reductions.

  Recruiting at 4 sites Universiteit Antwerpen · Antwerp, Antwerp and 3 other locations · NCT06825039

• Paraffin Wax plus Exercise for Improving Joint Movement in Burn Scars

  This study will test whether adding paraffin wax to exercise-based scar rehab helps adults with burn scars that cross a joint improve joint range of motion and function.

  Recruiting Medstar Health Research Institute · Washington D.C., District of Columbia · NCT06786884

• Hyaluronic acid plus recombinant collagen volumizing filler for facial wrinkles and sagging

  This trial will try a hyaluronic acid and recombinant collagen filler to reduce facial wrinkles, scars, and tissue laxity in non-smoking adults aged 18–70.

  Recruiting Taumedika s.r.l. · Roma · NCT06336044

• Comparing single-layer and double-layer closure techniques in cesarean sections

  This study is testing whether closing the uterus with one layer or two layers after a cesarean section affects the amount and length of spotting women experience afterward.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan, Mi · NCT06308172

• Comparing scar outcomes from different incision techniques in mastectomy

  This study is testing which type of incision technique during mastectomy leads to the best-looking scars for patients who aren't having immediate breast reconstruction.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06191159

• Comparing microneedling and dermabrasion for treating facial scars

  This study tests whether microneedling or dermabrasion works better to improve the look of new surgical scars on the face for adults.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06171386

• Evaluating SLI-F06 for improving scar appearance in healthy volunteers

  This study is testing a new treatment called SLI-F06 to see if it can improve the appearance of scars in healthy volunteers aged 18 to 65.

  Recruiting at 2 sites Phase 2 Scarless Laboratories, Inc. · Encinitas, California and 1 other locations · NCT05501327

• Comparing suture types for better scar outcomes in patients with skin of color

  This study is testing whether dissolvable or non-dissolvable stitches lead to better-looking scars for patients with skin of color after surgery.

  Recruiting at 3 sites University of Pittsburgh · Pittsburgh, Pennsylvania and 2 other locations · NCT05408117

• Using silicone tape to improve scars after abdominal surgery

  This study is testing if using silicone tape on abdominal scars after surgery can make them look better compared to leaving part of the scar without any treatment.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT04506255

• Repairing scars with tissue-engineered skin grafts

  This study is testing a new way to treat stubborn scars using skin grafts made from the patient's own cells to see if it can improve healing and reduce costs.

  Recruiting First Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT04389164

• Comparing partial breast irradiation to no irradiation for early breast cancer in women

  This study is testing if women with early breast cancer can skip radiation treatment after surgery without increasing their chances of the cancer coming back.

  Recruiting at 17 sites Danish Breast Cancer Cooperative Group · Santiago and 16 other locations · NCT03646955

• Comparing zinc oxide and petrolatum for healing surgical scars

  This study is testing whether zinc oxide ointment works better than petrolatum for healing and reducing scars after skin surgery.

  Recruiting Early Phase 1 University of Pittsburgh · Pittsburgh, PA, Pennsylvania · NCT03561376

NIH-funded research (19)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• SCAR Clinical Research Consortium: Understanding and Predicting Severe Skin Reactions

  A national network will study severe skin drug reactions like SJS/TEN and DRESS to improve diagnosis, severity measures, and future drug safety trials.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11464369

• Restoring the cornea’s support layer to reduce scarring

  Researchers are trying to restore the cornea’s supporting tissue to help people with corneal scarring from injury, infection, or congenital conditions.

  NIH research University of South Florida · Tampa, United States · NIH-11418376

• Turning scar-forming support cells into neurons to repair spinal cord injuries

  This project uses a cell-reprogramming approach to make support cells into new nerve cells to help people with spinal cord injuries regain function.

  NIH research University of Louisville · Louisville, United States · NIH-11393167

• How previous uterine scars lead to placenta accreta

  Researchers are looking at how uterine scars from prior cesarean deliveries change the uterus so the placenta can grow in too deeply, causing placenta accreta in pregnant people.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11319830

• Sutureless collagen gel repair for corneal scarring

  This work tests a suture-free, transparent collagen gel with healing cells to replace scarred cornea tissue and help people with vision loss from corneal scars.

  NIH research Stanford University · Stanford, United States · NIH-11250132

• Cell signals that control scarring during tendon healing

  This research looks at how two cell signals, mTORC1 and Stat3, affect scarring as tendons heal to help people with tendon injuries heal stronger and with less pain.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11238010

• Understanding how uterine scars affect placenta growth

  This study is looking into how past surgeries, like C-sections, can cause the placenta to grow too deeply into the uterus, and it aims to find ways to prevent or treat this condition by understanding the changes in the uterus that happen because of scar tissue.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11125991

• Investigating genetic factors that cause scarring in vocal folds after injury

  This study is looking at how certain genes might cause scars on the vocal folds, which can impact your voice, and it's using rabbits to help find better treatments for people with voice problems.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11082983

• Investigating how MFAP5 affects skin scar formation

  This study is looking at how certain cells in your body help heal wounds and form scars, focusing on a specific protein that might change how these cells work, with the hope of finding better ways to treat scars and improve healing for everyone.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11070206

• Repairing corneal scars without stitches using a special gel

  This study is testing a new, gentle way to treat corneal scarring by using a special gel that helps heal the eye and improve vision without stitches, making it a great option for people at risk of vision loss or blindness.

  NIH research Stanford University · Stanford, United States · NIH-11010339

• Understanding how specific signaling pathways affect scar formation during tendon healing

  This study is looking into how certain signals in the body affect the healing of tendon injuries, which can sometimes lead to pain and limited movement, with the goal of finding better ways to help people recover faster and more effectively.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10999409

• A new implant to reduce vocal fold scarring and improve voice quality

  This study is testing a new injectable implant that slowly releases medication to help heal the vocal folds, making it easier for people with voice problems to recover and improve their voice without causing more discomfort or scarring.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-10833645

• Protecting brain white matter in infants with oxygen deprivation

  This study is looking for ways to help babies who have had low oxygen at birth avoid brain problems by developing new treatments that support healthy brain growth and myelin development.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10833065

• Exploring how naked mole rat skin heals without scars

  This study is looking at how naked mole rats heal their skin without scars, and it hopes to find ways to help people heal better and avoid scars too.

  NIH research Boston University Medical Campus · Boston, United States · NIH-10831130

• Transforming scar tissue into healing skin

  This study is looking at how a special pathway in our bodies can help heal skin wounds better and reduce scarring, which could be great news for anyone dealing with skin injuries.

  NIH research New York University School of Medicine · New York, United States · NIH-10793563

• Investigating the role of Bcl-2 in vision loss from age-related macular degeneration

  This study is looking at how inflammation affects vision loss in older adults with age-related macular degeneration (AMD) and is exploring a protein called Bcl-2 to see if it plays a role in healing and could help find new treatments.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10733960

• Improving heart imaging without gadolinium contrast

  This study is testing a new way to take heart images that helps doctors see damaged heart tissue without using a special dye, making it safer for patients with kidney problems, especially those with a type of heart condition called non-ischemic cardiomyopathy.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-10665634

• Evaluating how cleft lip repair scars affect facial growth in small animals

  This study is looking at how scars from cleft lip surgery affect the growth of the face in small animals, so we can learn how to improve treatments for kids with cleft lip and palate.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10642519

• Improving heart rhythm treatment using advanced imaging techniques

  This study is looking to improve how we treat ventricular tachycardia, a serious heart issue, by creating a new imaging method that combines heart electrical activity with MRI scans, helping doctors find and treat the problem areas more effectively.

  NIH research Rochester Institute of Technology · Rochester, United States · NIH-10558577

Related topics

Quick answers

How many Scar clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (5 trials), China (3 trials), Canada (2 trials), Italy (2 trials), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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