SCAR Clinical Research Consortium: Understanding and Predicting Severe Skin Reactions
Official title: Severe Cutaneous Adverse Reaction (SCAR) Clinical Research Consortium (CRC)
Funded at Vanderbilt University Medical Center · NIH-11464369 · Data updated 2026-11-12
A national network will study severe skin drug reactions like SJS/TEN and DRESS to improve diagnosis, severity measures, and future drug safety trials.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 22, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,761,085 |
| NIH project number | 1U54AI205728-01 |
| Project ID | NIH-11464369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients experiencing or at risk for SCARs (SJS/TEN, DRESS, AGEP, GBFDE, SCAR-irAE) and diverse demographics who may contribute data or biospecimens.
✕Less likely to help
The grant focuses on infrastructure and discovery; individual participants not experiencing SCARs may not directly benefit.
What this research studies
This initiative creates a collaborative clinical and biological resource across 13 major centers, led by Vanderbilt, to map how severe cutaneous adverse reactions develop across diverse ages, sexes, and ethnicities. Researchers will collect clinical data and biological samples to identify genetic and biomarker factors linked to severity and outcomes. The project aims to develop validated tools for measuring how severe these reactions are and for readiness for future clinical trials and targeted therapies. The work will also support pilot projects to explore new drug targets and interventions for SCARs. A strong emphasis is placed on inclusivity, data sharing, and building infrastructure to accelerate translating findings into safer treatments.
Why it matters
Potential benefit: Patients could see faster, more accurate diagnosis and better-informed treatments for severe skin drug reactions in the future.
How similar studies have gone: Previous SCAR research networks have shown progress in understanding risk factors and developing clinical measures, but this consortium aims to advance readiness for trials and targeted therapies.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Phillips, Elizabeth — Vanderbilt University Medical Center
- Study coordinator: Phillips, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.