Repairing scars with tissue-engineered skin grafts
Official title: A Multicenter, Randomized, Controlled Clinical Trial of Tissue-engineered Skin Grafts With Autologous Scar Dermal Scaffolds for the Repair of Hypertrophic Scars
Run by First Affiliated Hospital, Sun Yat-Sen University · NCT04389164 · Data updated 2026-11-12
This study is testing a new way to treat stubborn scars using skin grafts made from the patient's own cells to see if it can improve healing and reduce costs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | Any age to 80 Years |
| Sex | All |
| Enrollment | 226 (estimated) |
| Sponsor | First Affiliated Hospital, Sun Yat-Sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | March 1, 2019 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2027 |
| Registry record updated | May 15, 2020 |
| Trial ID | NCT04389164 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients diagnosed with hypertrophic scars requiring surgical repair, with scar sizes between 10cm² and 200cm².
✕Probably not a fit
Patients with scars outside the specified size range or those who do not meet the inclusion criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on treating hypertrophic scars, which can lead to reduced quality of life and joint dysfunction. It aims to utilize tissue-engineered skin grafts made from autologous scar dermal scaffolds to improve scar repair outcomes. The approach seeks to address the limitations of current skin grafting methods, such as insufficient skin sources and high recurrence rates. By using the patient's own cells, the study hopes to enhance the survival rate of the grafts and reduce medical costs associated with scar treatment.
Why it matters
Potential benefit: If successful, this approach could significantly improve scar healing and reduce the recurrence of hypertrophic scars.
How similar studies have gone: While similar approaches have been explored, this specific method using autologous dermal scaffolds is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: The patient is diagnosed as hypertrophic scar and needs surgical repair; The scar size was 10cm2 to 200cm2, and the site was not limited; Patients with stable vital signs and tolerable operation indicated by routine examination; Patients in good mental state, can follow the doctor's advice, regular return; Those whom the researchers considered unsuitable for inclusion; Patients have participated in this study at any time in the past; Those whom the researchers considered unsuitable for inclusion; Patients have participated in this study at any time in the past. Exclusion Criteria: Those who did not meet the inclusion criteria were found after the selected subjects; The follow-up time after inclusion was less than 2 times, and the objective efficacy could not be evaluated (but the adverse reactions could be evaluated); Subjects who violate protocol requirements.
Where it's running
-
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Zhu Jiayuan
- Email: zhujiay@mail.sysu.edu.cn
- Phone: 86-20-87755766
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.