Investigating genetic factors that cause scarring in vocal folds after injury
Official title: Genetic pathways that contribute to fibrosis in iatrogenic vocal fold scar
Funded at University of Pittsburgh at Pittsburgh · NIH-11082983 · Data updated 2026-11-12
This study is looking at how certain genes might cause scars on the vocal folds, which can impact your voice, and it's using rabbits to help find better treatments for people with voice problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 5F31DC021614-02 |
| Project ID | NIH-11082983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced vocal fold scarring due to injury or other causes and are seeking better treatment options.
✕Less likely to help
Patients with voice disorders not related to vocal fold scarring may not benefit from this research.
What this research studies
This research focuses on understanding the genetic pathways involved in the formation of vocal fold scars, which can significantly affect a person's voice and quality of life. By examining the TGF-β signaling pathway, the study aims to identify specific genetic changes that contribute to fibrosis in vocal folds. Using a rabbit model, researchers will analyze the expression of genes and molecular components associated with vocal fold scarring. This comprehensive approach may lead to better treatment options for individuals suffering from voice disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for vocal fold scars, enhancing voice quality and overall quality of life for affected patients.
How similar studies have gone: Previous research has shown that targeting the TGF-β pathway can be effective in addressing fibrosis in other tissues, suggesting potential for success in this area as well.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Hary, Elizabeth — University of Pittsburgh at Pittsburgh
- Study coordinator: Hary, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.