Investigating genetic factors that cause scarring in vocal folds after injury
Genetic pathways that contribute to fibrosis in iatrogenic vocal fold scar
This study is looking at how certain genes might cause scars on the vocal folds, which can impact your voice, and it's using rabbits to help find better treatments for people with voice problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11082983 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic pathways involved in the formation of vocal fold scars, which can significantly affect a person's voice and quality of life. By examining the TGF-β signaling pathway, the study aims to identify specific genetic changes that contribute to fibrosis in vocal folds. Using a rabbit model, researchers will analyze the expression of genes and molecular components associated with vocal fold scarring. This comprehensive approach may lead to better treatment options for individuals suffering from voice disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced vocal fold scarring due to injury or other causes and are seeking better treatment options.
Not a fit: Patients with voice disorders not related to vocal fold scarring may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for vocal fold scars, enhancing voice quality and overall quality of life for affected patients.
How similar studies have performed: Previous research has shown that targeting the TGF-β pathway can be effective in addressing fibrosis in other tissues, suggesting potential for success in this area as well.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Hary, Elizabeth — University of Pittsburgh at Pittsburgh
- Study coordinator: Hary, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.