Understanding how uterine scars affect placenta growth
Official title: Dysregulation of Endometrial Invasibility Proximal to Uterine Scar as a Mechanism of Placenta Accreta
Funded at University of Connecticut Sch of Med/dnt · NIH-11125991 · Data updated 2026-11-12
This study is looking into how past surgeries, like C-sections, can cause the placenta to grow too deeply into the uterus, and it aims to find ways to prevent or treat this condition by understanding the changes in the uterus that happen because of scar tissue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | July 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $483,746 |
| NIH project number | 5R01HD112424-02 |
| Project ID | NIH-11125991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have had previous uterine surgeries, particularly cesarean deliveries, and are at risk for placenta accreta in subsequent pregnancies.
✕Less likely to help
Patients who have never had uterine surgery or those who are not pregnant may not benefit from this research.
What this research studies
This research investigates the condition known as placenta accreta, where the placenta invades too deeply into the uterus, often due to previous uterine scars from surgeries like cesarean sections. The study aims to uncover the cellular and molecular mechanisms that lead to this abnormal invasion, focusing on how the scar tissue alters the signaling environment in the uterus. By examining the inflammatory responses and the recruitment of specific cells at the site of the scar, the researchers hope to identify potential therapeutic targets to prevent or manage this serious condition. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for placenta accreta, potentially reducing the need for hysterectomies in affected women.
How similar studies have gone: While the specific mechanisms of placenta accreta are not fully understood, similar research approaches have shown promise in understanding other placental disorders, indicating potential for success in this area.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Kshitiz, Fnu — University of Connecticut Sch of Med/dnt
- Study coordinator: Kshitiz, Fnu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.